Janssen Pharmaceutica Nv

Leonard, Kristi A.

Rachel T Nishimura

David A Kummer

Hariharan Venkatesan

Kevin Douglas Kreutter

Craig R Woods

Ronald L Wolin

James Patrick Edwards

Aihua Wang

Kristi A Leonard

Maud J Urbanski

Umar Maharoof

Kent Barbay

Xiaohua Xue

Anne Fourie

Maxwell David Cummings

Steven D Goldberg

Kelly J McClure

Jennifer Diane Venable

Jianmei Wei

Gavin C Hirst

Wenying Chai

Virginia M Tanis

Connor L Martin

Elizabeth G Fennema

J Kent Barbay

Amy Y Shih

William Moore Jones

Taraneh Mirzadegan

Joan M Pierce

Kelly Ganamet

Kelly Lynn Ganamet

Anne M Fourie

Joan Pierce

Kelly Mcclure

Sultam compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with the KEAP1-Nrf2 interaction, such as inflammatory bowel disease, including Crohn's disease and ulcerative colitis.

Inhibitors of KEAP1-Nrf2 protein-protein interaction

The present invention comprises compounds of Formula I. wherein:R, R, R, R, R, R, R, Q, and Qare defined in the specification. The invention also comprises a method of treating or ameliorating a ROR-&#x3b3;-t mediated syndrome, disorder or disease, including wherein the syndrome, disorder or disease is selected from the group consisting of rheumatoid arthritis, psoriatic arthritis, and psoriasis. The invention also comprises a method of modulating ROR&#x3b3;t activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula I.

Phenyl and pyridinyl substituted imidazoles as modulators of ROR&#x3b3;T

The present invention comprises compounds of Formula I. wherein:R, Q, R, R, R, R, A, and Aare defined in the specification. The invention also comprises a method of treating or ameliorating a ROR-&#x3b3;-t mediated syndrome, disorder or disease, including wherein the syndrome, disorder or disease is selected from the group consisting of rheumatoid arthritis, psoriatic arthritis, and psoriasis. The invention also comprises a method of modulating ROR&#x3b3;t activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula I.

6-aminopyridin-3-yl pyrazoles as modulators of RORgT

The present invention comprises compounds of Formula I. wherein:R, R, R, R, R, R, R, and Q are defined in the specification. The invention also comprises a method of treating or ameliorating a ROR-&#x3b3;-t mediated syndrome, disorder or disease, including wherein the syndrome, disorder or disease is selected from the group consisting of rheumatoid arthritis, psoriatic arthritis, and psoriasis. The invention also comprises a method of modulating ROR&#x3b3;t activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula I.

Phenyl substituted pyrazoles as modulators of ROR&#x3b3;t

The present invention comprises compounds of Formula I. wherein:R, R, R, R, R, R, R, R, and Rare defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating ROR&#x3b3;t activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim

Alkyl linked quinolinyl modulators of ROR&#x3b3;t

Phenyl linked quinolinyl modulators of ROR&#x3b3;t

The present invention comprises compounds of Formula I. wherein: The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating ROR&#x3b3;t activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim

Quinolinyl modulators of ROR&#x3b3;t

The present invention comprises compounds of Formula I.  The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating ROR&#x3b3;t activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim

Heteroaryl linked quinolinyl modulators of RORgammat

Heteroaryl linked quinolinyl modulators of ROR&#x3b3;t

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San Diego, CA, United States of America

Rachel T Nishimura