Beth Israel Deaconess Medical Center, Inc.

Rachel Scheidegger

David C Alsop

A method for chemical exchange saturation transfer ('CEST') imaging that is more insensitive to off-resonance and magnetization transfer effects than other CEST methods is provided. Sn general, three different images are obtained: one obtained with radio frequency ('RF') saturation about a labeling frequency, one obtained with RF saturation about a reference frequency, and one obtained with RF saturation about both the labeling and reference frequencies. This method, termed saturation with frequency alternating radiofrequency irradiation (&#x201c;SAFARI&#x201d;), is also very robust to magnetic field inhomogeneities. The three images, referred to as a labeled image, reference image, and dual frequency image, are selectively combined to produce an image of the subject in which CEST contrast is present, but errors arising from off-resonance and magnetization transfer effects are substantially suppressed.

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Boston, MA, United States of America

Rachel Scheidegger