Other

Myrexis, Inc.

Myriad Pharmaceuticals, Inc.

Myriad Genetics, Inc.

Epicept Corporation

Rachel M Slade

Mark B Anderson

Warren S Weiner

Ruth J Walton

Yevgeniya Klimova

Robert J Halter

Jon Adam Willardsen

Kenton Zavitz

Ashantai J Yungai

Sui Xiong Cai

John P Manfredi

Songchun Jiang

Christine A Klein

Ashok Bajji

Andrew Gassman

Eric Delmar

Adam Willardsen

Yevgeniya I Klimova

Esther Arranz

Jayasree M Srinivasan

Leena Bhoite

The present disclosure relates to novel indole and tetrahydroindole core compounds useful for the treatment of disorders associated with a defect in vesicular transport (e.g., axonal transport).

Compounds for Alzheimer's disease

The invention provides novel compounds useful for the treatment of neurodegenerative disorders including Alzheimer's disease and dementia. The compounds have a substituents chosen from -L-C(&#x2550;O)OH, -L-CH&#x2550;CHC(&#x2550;O)OH, -L-C(&#x2550;O)NH, -L-C(&#x2550;O)NH(Calkyl), -L-C(&#x2550;O)N(Calkyl), -L-S(&#x2550;O)(Calkyl), -L-S(&#x2550;O)NH, -L-S(&#x2550;O)N(Calkyl), -L-S(&#x2550;O)NH(Calkyl), -L-C(&#x2550;O)NHOH, -L-C(&#x2550;O)CHNH, -L-C(&#x2550;O)CHOH, -L-C(&#x2550;O)CHSH, -L-C(&#x2550;O)NHCN, -L-NHC(&#x2550;O)OR, -L-C(&#x2550;O)NHR, -L-NH(C&#x2550;O)NHR, -L-C(&#x2550;O)N(R), -L-NH(C&#x2550;O)N(R), -L-sulfo, -L-(2,6 difluorophenol), -L-phosphono, and -L-tetrazolyl, where L is a linker.

Novel pyrrole derivatives are disclosed as A&#x3b2;-lowering agents for the treatment and prevention of neurodegenerative disorders characterized by the formation or accumulation of amyloid plaques comprising the A&#x3b2;peptide.

Pyrrole derivatives as therapeutic compounds

Disclosed are 1-arylamino-phthalazines, 4-arylamino-benzo[d][1,2,3]triazines, and analogs thereof effective as activators of caspases and inducers of apoptosis. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

Pharmaceutical compounds as activators of caspases and inducers of apoptosis and the use thereof

Compounds for alzheimer's disease

Compounds and pharmaceutical compositions containing the same are provided, which are useful in therapeutic treatment or prevention of various diseases.

Compounds, compositions, and methods employing same

Growing community of inventors

Salt Lake City, UT, United States of America

Rachel M Slade