Pfizer Corporation

Rachel Jane Roth Flach

David Andrew Griffith

Kevin James Filipski

Yuan Zhang

Bethany Lyn Kormos

Matthew Richard Reese

Leanne Marie Buzon

Samit Kumar Bhattacharya

Luis Angel Martinez-Alsina

Russell Alan Miller

Christopher Ryan Butler

Brian Kenneth Raymer

Kimberly O'Keefe Cameron

Shenping Liu

Luis Angel Martinez Alsina

Kevin Francis Deboyace

Kiyoyuki Omoto

Described herein are compounds of Formula I, wherein the variables are defined herein, their use as branched-chain alpha keto acid dehydrogenase kinase inhibitors and/or degraders, pharmaceutical compositions containing such compounds and their use to treat, for example, diabetes, kidney disease, NASH and heart failure.

BCKDK inhibitors and/or degraders

Described herein are compounds of Formula I, wherein R, R, and Rare defined herein, their use as branched-chain alpha keto acid dehydrogenase kinase inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to treat, for example, diabetes, NASH and heart failure.

BCKDK inhibitors

Growing community of inventors

Rockland, MA, United States of America

Rachel Jane Roth Flach