Senomyx, Inc.

Rachel D A Kimmich

Catherine Tachdjian

Vincent Darmohusodo

Qing Chen

Xiao-Qing Tang

Sara L Adamski-Werner

Xiaodong Li

Donald Karanewsky

Albert Zlotnik

Guy Servant

Hong Zhang

Richard Masten Fine

Joseph R Fotsing

Boris Klebansky

Feng Zhang

Marketa Rinnova

Jeffrey Robert Hammaker

Haitian Liu

Xinshan Kang

Goran Petrovic

Jeffrey Yamamoto

Mark Zoller

Andrew P Patron

Farid Bakir

Chad Priest

Rhondi Shigemura

Claudia Averbuj

Marketa Lebl-Rinnova

The present invention includes methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors, and modifiers capable of modulating chemosensory receptors and their ligands. The present invention also includes modifiers of chemosensory receptors and their ligands having Formula (I), its subgenus, and specific compounds. Furthermore, the present invention includes ingestible compositions comprising the modifiers of chemosensory receptors and their ligands and methods of using the modifiers of chemosensory receptors and their ligands to enhance the sweet taste of an ingestible composition or treat a condition associated with a chemosensory receptor. In addition, the present invention include processes for preparing the modifiers of chemosensory receptors and their ligands.

Modulation of chemosensory receptors and ligands associated therewith

The inventions disclosed herein relate to man-made bi-aromatic amide compounds that, when contacted with comestible food or drinks or pharmaceutical compositions at concentrations preferably on the order of about 100 ppm or lower, serve as sweet taste modifiers, sweet flavoring agents, or sweet flavor enhancers, for use in foods, beverages, and other comestible products, or orally administered medicinal products or compositions, optionally in the presence of or in mixtures with conventional flavoring agents such as known natural saccharide sweeteners and previously known artificial sweeteners.

Bis-aromatic amides and their uses as sweet flavor modifiers, tastants, and taste enhancers

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San Diego, CA, United States of America

Rachel D A Kimmich