Tel Aviv University

Rachel Cohen-Kupiec

Beka Solomon

Tamir Tuller

Hadas Zur

Genetically modified cells with at least one codon substituted to a synonymous codon, and with modified replicative fitness as compared to the unmodified cell, wherein a slower translating synonymous codon increases replicative fitness and a faster translating codon decreased replicative fitness are provided. Further, vaccine composition comprising those cells as well as methods for modifying replicative fitness of a cell are provided.

Methods for modifying the growth rate of a cell

Anti-A&#x3b2;P scFvs and single domain antibodies were generated, and when these antibodies were displayed on filamentous phage or as soluble protein molecules, stabilized by the maltose binding protein, they could prevent the fibrilization of A&#x3b2;p 1-40 and disaggregate A&#x3b2;p 1-40 fibrils generated in vitro. The anti-A&#x3b2;p scFv antibodies also stained amyloid neuritic plaques on slices from transgenic mice. The anti-A&#x3b2;P scFv and single domain antibodies can be used for inhibiting or treating Alzheimer's disease.

Single chain antibodies against &#x3b2;-amyloid peptide

Anti-A&#x3b2;P scFvs and single domain antibodies were generated, and when these antibodies were displayed on filamentous phage or as soluble protein molecules, stabilized by the maltose binding protein, they could prevent the fibrilization of Abp 1-40 and disaggregate Abp 1-40 fibrils generated in vitro. The anti-A&#x3b2;p scFv antibodies also stained amyloid neuritic plaques on slices from transgenic mice. The anti-A&#x3b2;P scFv and single domain antibodies can be used for inhibiting or treating Alzheimer's disease.

Growing community of inventors

Tel Aviv, Israel

Rachel Cohen-Kupiec