University of Illinois

Vanquish Oncology, Inc.

Johns Hopkins University

Rachel C Botham

Paul Joseph Hergenrother

Mark J Gilbert

Timothy M Fan

Michael K Handley

Theodore Michael Tarasow

Gregory J Riggins

Avadhut D Joshi

Howard S Roth

Michael J Handley

Theodore M Tarasow

Compositions and methods for the induction of cell death, for example, cancer cell death. Combinations of compounds and related methods of use are disclosed, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells. The disclosed drug combinations can have lower neurotoxicity effects than other cancer therapies that achieve the same or similar therapeutic effect.

Procaspase combination therapy for glioblastoma

The invention provides compositions and methods for the induction of cell death, for example, cancer cell death. Combinations of compounds and related methods of use are disclosed, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells. The disclosed drug combinations can have lower neurotoxicity effects than other compounds and combinations of compounds.

Procaspase 3 activation by combination therapy

The invention provides compositions and methods for the induction of cell death, for example, cancer cell death. Combinations of compounds and related methods the use are disclosed, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells. The disclosed drug combinations can have lower neurotoxicity effects than other compounds and combinations of compounds.

Potent anticancer activity via dual compound activation

Growing community of inventors

Champaign, IL, United States of America

Rachel C Botham