Leland Stanford Junior University

Abbott Cardiovascular Systems, Inc.

Johns Hopkins University

Rachel Bright

Daria D Mochly-Rosen

Stephen D Pacetti

Paul M Consigny

Dariush Davalian

Irina Astafieva

Jinping Wan

Katsuyuki Murase

Li Zhao

John Joseph Stankus

Kam W Leong

Florian Ludwig

Corinne Bright

Eric Churchill

Syed Fayaiz Ahmed Hossainy

Syed F A Hossainy

Ronald W Heil, Jr

Fozan El-Nounou

Jeffrey T Ellis

Florian Niklas Ludwig

A method for protection of tissues subject to ischemic and/or reperfusion damage is provided. The method includes administering to the tissue a composition comprising nanodevices. The nanodevices can take the form of, for example, polymeric nanoparticles or lipidic nanoparticles. The nanodevices also find use in methods for reducing ischemic injury in tissue at risk of such injury, such as heart and brain tissue.

Method and use of nano-scale devices for reduction of tissue injury in ischemic and reperfusion injury

The present invention relates to the regional delivery of therapeutic agents for the treatment of vascular diseases wherein regional delivery refers to delivery of a therapeutically effective amount of the therapeutic agent to an area of the vessel that includes not only afflicted tissue but non-afflicted tissue at the periphery of the afflicted tissue as well.

Regional delivery of therapeutic agents for the treatment of vascular diseases

A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (Apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (Apo A-I) synthetic peptide, or combination of an Apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various Apo A-I mimetic peptides, or endogenous Apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous Apo A-I.

Sustained release of APO A-I mimetic peptides and methods of treatment

Methods of increasing blood flow in a mammalian brain blood vessel characterized by, or otherwise experiencing, decreased blood flow due to an ischemic or other hypoxic event, vasoconstriction or vasospasm following hemorrhagic stroke; due to chronic high blood pressure; and/or due to idiopathic causes are provided. The method for increasing blood flow in such a mammalian brain blood vessel includes administering to a patient in need thereof a therapeutically effective amount of an inhibitor of &#x3b4; protein kinase C. In certain embodiments, the inhibitor can be chronically administered without causing desensitization of the patient to the inhibitor. Kits for increasing blood flow in a mammalian brain blood vessel characterized by, or otherwise experiencing, decreased blood flow due to an ischemic or other hypoxic event, vasoconstriction or vasospasm following hemorrhagic stroke; due to chronic high blood pressure; and/or due to idiopathic causes are provided.

Methods of increasing cerebral blood flow

Sustained release of Apo A-I mimetic peptides and methods of treatment

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Palo Alto, CA, United States of America

Rachel Bright