Centre National De La Recherche Scientifique

Université Joseph Fourier - Grenoble 1

Galderma Research & Development

Rachel Auzely-Velty

Jean-Guy Boiteau

Craig Steven Harris

Thibaut Gerfaud

Loïc Tomas

Laura Jing Jing

Tamiris Figueiredo

Bogdan Catargi

Valérie Ravaine

Léa Messager

Caroline Creuzet

Emilie Hachet

Lea Messager

Valerie Ravaine

A new hydrogel made of crosslinked glycosaminoglycans, particularly crosslinked hyaluronic acid, chondroitin or chondroitin sulfate, having reversible linkages using boronic acid or boroxole derivatives leading to new benefits. Glycosaminoglycans that are crosslinked via an alkoxyboronate ester anion formed between a diol portion of a diol-functional moiety grafted to a first glycosaminoglycan and a boronate hemiester grafted to a second glycosaminoglycan.

Method of crosslinking glycosaminoglycans

Polymer composition comprising a mixture of PBA modified HA polymer grafted on at least a hydroxyl with a group comprising phenylboronic acid and Cis-diol modified HA polymer grafted on at least a hydroxyl with a group comprising a cis-diol. Injectable or implantable glucose-sensitive hydrogels comprising a this polymer composition.

Glucose responsive hydrogel comprising PBA-grafted hyaluronic acid (HA)

The invention relates to a thermosensitive (poly(ethylene oxide) poly(propylene oxide))-acetal derivative, which can be used to functionalize chitosan, and to the process for the preparation thereof. The invention therefore also relates to a process for functionalizing chitosan by grafting this thermosensitive copolymer and optionally another thermosensitive polymer, poly(ethylene oxide). A subject of the invention is also a chitosan-(poly(ethylene oxide) poly(propylene oxide))-poly(ethylene oxide) derivative which has the advantage of being water-soluble at physiological pH. The invention therefore also relates to the aqueous compositions comprising this derivative and to the use of this composition for the manufacture of gel by heating.

Process for preparing thermosensitive (poly(ethylene oxide) poly(propylene oxide)) derivatives that can be used to functionalize chitosan

Growing community of inventors

Le Gua, France

Rachel Auzely-Velty