Biochem Pharma Inc.

Vertex Pharmaceuticals, Inc.

Cytovia, Inc.

Shire Biochem, Inc.

Viro Chem Pharma, Inc.

Vertex Pharmaceuticals (canada) Incorporated

Rabindra Rej

Giorgio Attardo

Marc Courchesne

Laval Chan Chun Kong

Sanjoy Kumar Das

Carl Poisson

Constantin G Yannopoulos

Real Denis

Serge Lamothe

Yves St-Denis

Wuyi Wang

France Barbeau

Yao-Chang Xu

Dieu Nguyen

Elaine Lebeau

Irina Motorina

Jean-Francedillaois Lavall Ee

Tibor Breining

Jean Louis Kraus

Sui Xiong Cai

Boulos Zacharie

Nghe Nguyen-Ba

Songchun Jiang

Guy Falardeau

Shaun Abbott

Richard Storer

Bernard Belleau, Deceased

Denis Labrecque

Réal Denis

Jean-Louis Kraus

Serge Lamonthe

Jean-Francedillaois Lavallee

Compounds and methods for the treatment or prevention of flavivirus infections

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The present invention is directed to substituted 4H-chromenes, 2H-chromenes, chromans and analogs thereof, represented by the general Formula (I) wherein R, A, B, X, Y, Z and dotted lines are defined herein. The present invention also relates to the discovery that compounds having Formula (I) are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

Substituted 4H-chromens, 2H-chromenes, chromans and analogs as activators of caspases and inducers of apoptosis and the use thereof

The present invention is directed towards novel compounds that are effective inhibitors of integrins, particularly &agr; &bgr; or &agr; integrins such as &agr; &bgr; and &agr; &bgr; . One embodiment of the present invention comprises a compound of formula (I) or formula (II) or a pharmaceutically acceptable salt, solvate, or metabolic precursor thereof. R1, R2, R3, and R4 are defined herein.

Quinolizinones as integrin inhibitors

Antiviral phosphonate nucleotides

This invention relates to a naphthoquinone derivatives, to processes and to intermediates for preparing these derivatives, to pharmaceutical composition and to the use of these derivatives as antitumor agents in mammals.

Antineoplastic heteronapthoquinones

Processes antineoplastic heteronaphthoquinones

Novel pyrano heterocyclic anthracycline derivatives are described, which are useful in the treatment of cancer and tumors, such as breast cancer, leukemia, lung cancer, colon cancer, ovarian cancer, renal cancer, and melanoma. As well, these compounds may be used ex vivo for the treatment of cancerous bone marrow before retransplanting said marrow in a patient. Pharmaceutical compositions and methods of preparing the compounds are also described.

Heterocyclic anthracycline analogs

Growing community of inventors

Montreal, Canada

Rabindra Rej