Centre National De La Recherche Scientifique

Assistance Publique-Hopitaux De Paris

Institut National De La Recherche Scientifique

Universite Paris Cité

Ecole Nationale Superieure De Chimie De Paris

Institut National De La Sante Et De La Recherche Medicale

Université De Paris

Rabah Gahoual

Nathalie Mignet

Pascal Houze

Hugo Salmon

The present invention relates to an asymmetric flow field-flow fractionation device () configured to separate a sample () of particles () dispersed in a liquid mobile phase (), the device including a fractionation microchannel () comprising a sample inlet, a sample outlet, an auxiliary microchannel () comprising an auxiliary outlet, a semipermeable membrane () separating the fractionation microchannel () and the auxiliary microchannel (), said membrane being permeable to liquid and being configured to maintain the particles () in said fractionation microchannel (), the fractionation microchannel () being superimposed on the auxiliary microchannel (), wherein the device () comprises two layers (), each layer being with a microfabricated recess () which thickness (t) is less than 100m, the membrane () being mechanically held in between the two layers (), the recesses () respectively defining the fractionation microchannel () and the auxiliary microchannel () on each side of the membrane ().

Microfluidic asymmetric flow field-flow fractionation device and method of using the same

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Paris, France

Rabah Gahoual