Sionex Corporation

The Charles Stark Draper Laboratory, Inc.

Amsel Medical Corporation

Dh Technologies Development Pte. Ltd.

Northeastern University

Massachusetts Eye and Ear Infirmary

Raanan A Miller

Erkinjon G Nazarov

Gary Alan Eiceman

Evgeny Krylov

John A Wright

Arnold Miller

Nir Lilach

Lawrence A Kaufman

William Edelman

Douglas B Cameron

David B Wheeler

Quan Shi

C James Morris

Markus Zahn

Anthony D Bashall

Angela M Zapata

Cristina E Davis

Boris Tadjikov

Stephen L Coy

Paul Vouros

Stephen D Kendig

William L Robbins

Mark C Terrell

Clayton Morris

Jeffrey T Borenstein

Joan W Miller

Mark Joseph Mescher

Edward T Bullister

Mitchell L Hansberry

Evangelos S Gragoudas

Anthony P Adamis

Christopher E Dubé

Kenneth A Markoski

Erikinjon G Nazarov

Daren Levin

Muning Zhong

Evgeny Krylova

Avraham Ram Lore

Marcie G Weinstein

Apparatus and methods for occluding hollow body structures, such as blood vessels, and for attaching tissue layers and/or non-tissue layers together by providing implantable elements on opposite sides of the structure or layers and drawing the implants together to occlude the body structure and/or bring the layers together. The implants are deliverable in a low-profile configuration and self-expand to an enlarged configuration. The implantable elements are delivered by transfixing the body structure, then releasing the implants on opposite sides of the body structure and drawing the implants together to effect an occlusion or attachment. The implants are configured to apply oppositely directed forces to opposite surfaces of the tissue layers at alternate, circumferentially spaced locations and may constrain the tissue in a serpentine pattern or in a direct clamping pattern. The implants grip the tissue in a manner that defines a pressure zone about the transfixion aperture that prevents leakage from the aperture.

Methods and apparatus for fastening and clamping tissue

Apparatus and methods for occluding hollow body structures, such as blood vessels, and for attaching tissue layers together by providing implantable elements on opposite sides of the structure or tissue layers and drawing the implants together to occlude the body structure and/or bring the tissue layers together. The implants are deliverable in a low-profile configuration and self-expand to an enlarged configuration. The implantable elements are delivered by transfixing the body structure, then releasing the implants on opposite sides of the anatomical structure to urge the layers together to effect an occlusion or attachment. The implants are configured to apply oppositely directed forces to opposite surfaces of the tissue layers at alternate, circumferentially spaced locations and may constrain the tissue in a serpentine pattern or in a direct clamping pattern. The implants grip the tissue in a manner that defines a pressure zone about the transfixion aperture that prevents leakage from the aperture. The invention can be used to fasten tissue to non-tissue.

Methods and apparatus for clamping tissue and occluding tubular anatomical structures

Methods and devices for temporarily occluding blood vessels are provided for use in emergency conditions to control trauma-induced hemorrhaging. An occlusion device is delivered and deployed through a rapidly introduced, percutaneously placed needle that carries an occlusion device in readiness to be deployed out of the needle. The deployed occlusion device applies pressure to the target blood vessel to control blood loss.

Apparatus and method for temporary occlusion of blood vessels

One-piece tissue fasteners are provided for securing two or more tissue layers to each other. Delivery devices are described by which a tandem array of such fasteners can be delivered and deployed to secure tissue layers in a number of locations without requiring removal or reloading of the removal tool.

Method and apparatus for serial deployment of multiple tissue fasteners

Apparatus and methods for occluding hollow body structures, such as blood vessels, and for attaching tissue layers together by providing implantable elements on opposite sides of the structure or tissue layers and drawing the implants together to occlude the body structure and/or bring the tissue layers together. The implants are deliverable in a low-profile configuration and self-expand to an enlarged configuration. The implantable elements are delivered by transfixing the body structure, then releasing the implants on opposite sides of the body structure and drawing the implants together to effect an occlusion or attachment. The implants are configured to apply oppositely directed forces to opposite surfaces of the tissue layers at alternate, circumferentially spaced locations and may constrain the tissue in a serpentine pattern or in a direct clamping pattern. The implants grip the tissue in a manner that defines a pressure zone about the transfixion aperture that prevents leakage from the aperture. The implants have a low profile in that they have a relatively short axial dimension relative to their deployed diameter.

Apparatus for fastening tissue and occluding tubular body structures

Method and apparatus for delivering multiple tissue fasteners with needle and fastener assemblies each of which comprises a hollow needle adapted to be passed through tissue layers to be fastened, the needle containing a proximal and a distal implant, the implants being configured to self-expand when ejected from the needle, the implants being lockable to each other after ejection in response to drawing the implants together with tissue gripped between the implants.

Method and apparatus for delivering multiple tissue fasteners

Apparatus and methods are provided for occluding blood vessels and other anatomical structures. Occlusion devices are delivered percutaneously and extraluminally through a small gauge needle and include expandable elements that are deployable on opposite sides of a target vessel to be occluded. When positioned about the vessel the elements are expanded and brought together to compress and occlude the vessel. Embodiments include those adapted for temporary as well as permanent use.

Apparatus and methods for occlusion of blood vessels

Catheter-based devices and methods for endoluminally accessing and occluding hollow anatomical structures are disclosed. Occlusion clips are contained in one or more needles that pierce opposing walls of the anatomical structure to deploy the clips externally of the structure. The clips then are drawn together to press the opposing anatomical walls together.

Method and apparatus for intraluminally occluding hollow or tubular body structures

Methods and apparatus are provided for fastening or clamping tissue to tissue or non-tissue layers and for occluding tubular body structures. Tissue fasteners having separate proximal and distal implants, each with self-expanding, radially extending legs are connected together on opposite sides of tissue and non-tissue layers. The legs of the proximal and distal implants are interdigitated in the absence of such layers.

Apparatus and methods for clamping tissue layers and occluding hollow anatomical structures utilize a pair of implants, each having deployable radially extending legs that clamp the layers together. The implants are locked together by a separate pin that also transfixes the tissue layers.

Apparatus and methods for clamping tissue layers and occluding hollow vessels

Apparatus and methods for occluding hollow body structures, such as blood vessels, and for attaching tissue layers together by providing implantable elements on opposite sides of the structure or tissue layers and drawing the implants together to occlude the body structure and/or bring the tissue layers together. The implants are deliverable in a low profile configuration and self-expand to an enlarged configuration. The implantable elements are delivered by transfixing the body structure, then releasing the implants on opposite sides of the body structure and drawing the implants together to effect an occlusion or attachment. The implants are configured to apply oppositely directed forces to opposite surfaces of the tissue layers at alternate, circumferentially spaced locations and may constrain the tissue in a serpentine pattern or in a direct clamping pattern. The implants grip the tissue in a manner that defines a pressure zone about the transfixion aperture that prevents leakage from the aperture.

Method and apparatus for clamping tissue layers and occluding tubular body structures

A system for occluding a hollow structure, the system comprising: a plurality of occluders; and an applicator for storing the plurality of occluders and serially delivering the occluders so as to occlude the hollow structure.

Apparatus and methods for fastening tissue layers together with multiple tissue fasteners

The invention relates generally to ion mobility based systems, methods and devices for analyzing samples and, more particularly, to sample pre-separation and amplification.

Methods and apparatus for enhanced ion based sample detection using selective pre-separation and amplification

The invention relates generally to systems, methods and devices for analyzing samples and, more particularly, to systems using a mass analyzer in combination with a differential mobility spectrometer to enhance the analysis process of constituents of a sample.

Combined mass and differential mobility spectrometry and associated methods, systems, and devices

A ion mobility-based analyzer system including a first ion mobility-based filter for passing selected ions through a time-varying field where the time-varying field being compensated by an adjustable compensation setting. The analyzer also includes a second ion mobility-based filter for receiving a first portion of ions from the first ion mobility-based filter. The second ion mobility-based filter includes a voltage gradient for separating ions of the first portion of ions where the ions have associated retention times based on their times of flight through the voltage gradient. The second ion mobility-based filter includes a detector for detecting the ions at their retention times. The analyzer system further includes a display that displays the detected ions in a plot relating the retention times of the ions in the second ion mobility-based filter with compensation settings of the first ion mobility-based filter.

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Chestnut Hill, MA, United States of America

Raanan A Miller