University of Sharjah

Raafat A El-Awady

Taleb H Altel

Srinivasulu Vunnam

Farah Ibrahim Al-Marzooq

Hany A Omar

Cijo George Vazhappilly

A compound represented by following formula I: according to the present disclosure. The disclosed compound is useful in the treatment of many disease states related to cell proliferation. In particular, new pyran derivatives are provided along with processes for preparations and methods for pharmaceutical applications, for example, as anticancer agents. The compound was found to have antiproliferative effects against multiple cancer cell lines and showed low toxicity to normal fibroblasts. The disclosed compound also exhibited anticancer properties by inducing caspase-mediated cell death mechanisms and arresting cancer cell progression. Further, the compound represented by Formula I targets multiple key proteins/enzymes, including thioredoxin reductase, glutathione reductase, transferrin receptors, inisitol-3-phosphate synthase, cystolic aminopeptidase, and transketolase, which are over-expressed in tumor cells.

Heterocyclic systems and pharmaceutical compositions thereof

Novel heterocyclic fused systems are disclosed herein which possess numerous biological activities, including but not limited to antibacterial activity, and usefulness to the treatment of many disease states, such as pathogenic infections. In particular, new imidazoles are disclosed along with related processes of preparation and methods of use as antibacterial agents. The disclosed compounds were found to be active against several Gram-positive bacteria, includingand, and were also found to be active against several species of multi-drug resistant, such as, and

Growing community of inventors

Sharjah, United Arab Emirates

Raafat A El-Awady