Battelle Memorial Institute

R Shane Addleman

Glen E Fryxell

Thomas S Zemanian

Christopher Lyle Aardahl

Oleg B Egorov

Feng Zheng

S Kamakshi Sundaram

Brad Busche

Brian J Riley

Thomas J Weber

Colette A Sacksteder

An ATR-FTIR device and system are described that defect live-cell responses to stimuli and perturbations in real-time. The system and device can monitor perturbations resulting from exposures to various physical, chemical, and biological materials in real-time, as well as those sustained over a long period of time, including those associated with stimuli having unknown modes-of-action (e.g. nanoparticles). The device and system can also be used to identify specific chemical species or substances that profile cellular responses to these perturbations.

System, device, and methods for real-time screening of live cells, biomarkers, and chemical signatures

Backfilled, self-assembled monolayers and methods of making the same are disclosed. The self-assembled monolayer comprises at least one functional organosilane species and a substantially random dispersion of at least one backfilling organosilane species among the functional organosilane species, wherein the functional and backfilling organosilane species have been sequentially deposited on a substrate. The method comprises depositing sequentially a first organosilane species followed by a backfilling organosilane species, and employing a relaxation agent before or during deposition of the backfilling organosilane species, wherein the first and backfilling organosilane species are substantially randomly dispersed on a substrate.

Backfilled, self-assembled monolayers and methods of making same

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Benton City, WA, United States of America

R Shane Addleman