Biocryst Pharmaceuticals, Inc.

R Scott Rowland

Yarlagadda Sudhakara Babu

Pooran Chand

Shri Niwas

Pravin L Kotian

Yahya El-Kattan

Tsu-Hsing Lin

J Claude Bennett

Certain cyclic compounds are presented as well as their use for inhibiting paramyxovirus neuraminidase. The compounds are represented by the following formulas:

Compounds useful for inhibiting paramyxovirus neuraminidase

Compounds of formula (I) are useful as inhibitors of trypsin like serine protease enzymes such as thrombin, factor VIIa, factor Xa, TF/FVIIa, and trypsin. These compounds could be useful to treat and/or prevent clotting disorders, and as anticoagulating agents.

Biaryl compounds as serine protease inhibitors

The present invention is concerned with new compounds, and particularly those having a fused bicyclic ring substituted with an amidine moiety. These compounds are each potent inhibitors of Factor D of the alternate pathway of complement, C1s of the classical pathway of complement, Factors Xa, XIIa, VIIa and thrombin of the coagulation pathway, plasmin in the fibrinolytic pathway, and kallikrein and high molecular weight kininogen in the inflammatory pathways. These proteases, which have serine in their active site, are called serine proteases and they are pivotal to most of the processes of inflammation and coagulation. In fact, these various systems are interactive with one another and it is difficult to activate one pathway without it influencing the others.

Compounds useful in the complement, coagulat and kallikrein pathways and method for their preparation

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Hoover, AL, United States of America

R Scott Rowland