The General Hospital Corporation

Other

Palomar Medicaltechnologies, Inc.

Massachusetts Institute of Technology

Blossom Innovations, LLC

Freedom-2, Inc.

Coherent, Inc.

Candela Corporation

Endovasix, Inc.

United States of America, As Represented by the Secretary of the Navy

University of Texas System

The United States of America

Massachusetts General Hospital Corporation

The General Hosptial Corporation

Seymour Light, Inc.

R Rox Anderson

William A Farinelli

Dieter Manstein

Gregory B Altshuler

Walfre Franco

Lilit Garibyan

Joshua Tam

Henry Hin Lee Chan

Vincent Zuo

Fernanda Hidemi Sakamoto

Martin Purschke

Craig A Drill

Emilia Javorsky

Joseph Ting

Apostolos G Doukas

Yacov Domankevitz

Anna N Yaroslavsky

Ian W Hunter

Kenton W Gregory

Warren M Zapol

Robert H Webb

James C Hsia

J Michael Yarborough

Gerald M Mitchell

Colin J H Brenan

Kathleen McMillan

Andrei V Erofeev

John A Parrish

Edward Victor Ross

Luca Zazzeron

Min Yao

George Marcellino

Edwin K Joe

Susanna K Mlynarczyk-Evans

Peter J Dwyer

Susanna K Mlynarczyk

Gerard Van Hamel Platerink

Mathew Avram

Wikunda Limpiangkanan

Keng Hui Lim

Bernhard Ortel

Victor C Esch

Nikiforos Kollias

James C Weaver

Henry Zenzie

Terry O Herndon

James G Burke, Iii

Michael R Hamblin

Elizabeth Sebern

Milind Rajadhyaksha

Andrew J Radl

Quang Q Tran

Ajay Shah

Vincent Hok Liu

Michael Z Smirnov

Andrea Willey

Lynn A Drake

Eliot F Battle

Matthew M Avram

Joel N Jimenez-Lozano

Falguni Asrani

Melanie Grossman

Joseph A Grocela

Nayantara Bhatta

Scott Prahl

Kachiu Lee

Iris Kedar Rubin

Oge Onwudiwe

Kirby Vosburgh

Ryan Thomas Russell

Marc-Alan Levine

Stephen J Hebert

William Neil Everett

Jayant D Bhawalkar

Michael V Pishko

Howard A Green

Ethan A Lerner

Ilya Yaroslavsky

Dilip Y Paithankar

Adela Ben-Yakar

Michael R Lerner

Steven M Zeitels

Reginald Birngruber

Ned Allen Godshall

Eduardo U Sucgang

Michael Smotrich

Mei X Wu

Salvador Gonzalez

Esmeralda Ibarra-silva

Robert Gillies

Christopher L Hoy

Misbah H Khan

Sergey B Biruchinsky

Adam B Raff

Daniela Kroshinsky

Antonio Ortega-Martinez

Jeffrey Shuhaiber

Ying Wang

Elizabeth A Gift

T R Gowrishankar

Exemplary methods and systems can be provided for resurfacing of skin that include formation of a plurality of small holes, e.g., having widths greater than about 0.2 mm and less than about 0.7 mm or 0.5 mm, using a mechanical apparatus. Compressive and/or tensile forces can then be applied to the treated region of skin as the damage heals to facilitate hole closure, and provide enhanced and/or directional shrinkage of the treated skin area.

Method and apparatus for dermatological treatment

A method for treating vascular diseases is provided. The method includes fabricating a sterile ice slurry including water and ice particles, cooling the sterile ice slurry to a predetermined temperature, and injecting the sterile ice slurry into a desired tissue region. The desired tissue region includes perivascular adipose tissue.

Injectable slurries and methods of manufacturing the same

Systems and methods are provided for performing a hair transplant using a hair transplant device. The hair transplant device comprises a coring needle, a splitting needle, a housing, and a user interface. The coring needle forms a coring lumen configured to extract a hair follicle from a donor site. The splitting needle is configured to create an opening in a recipient site. The housing at least partially surrounds one of the coring needle and the splitting needle. The user interface extends from the housing and is movable relative to the coring needle to push the hair follicle from the coring lumen into the opening in the recipient site formed by the splitting needle.

Systems and methods for hair transplant

Systems and methods for removing carbon monoxide from whole blood are provided. In one configuration, an extracorporeal phototherapy system includes an oxygenator and a light source configured to output light and arranged to emit the light output by the light source onto at least one surface of the oxygenator. The oxygenator includes a plurality of membrane layers each having a plurality of microporous hollow fiber membranes. The plurality of microporous hollow fiber membranes each include an external surface and an internal channel. Each of the plurality of membrane layers may be rotationally offset with respect to an adjacent layer. The oxygenator further includes a gas inlet port in fluid communication with a first end of the internal channels, a gas outlet port in fluid communication a second end of the internal channels, a blood inlet port, and a blood outlet port.

System and method for extracorporeal carbon monoxide removal with phototherapy

Described herein are compositions comprising, and methods for using, biocompatible cold slurries and methods of administering the same to provide reversible inhibition of peripheral nerves in a subject in need thereof.

Compositions and methods for treatment of neurological disorders

One aspect of the invention provides a slurry comprising: a plurality of sterile ice particles having a largest cross-sectional dimension less than about 1.5 mm; and a biocompatible surfactant. Another aspect of the invention provides a slurry including: a plurality of sterile ice particles having a largest cross-sectional dimension less than about 1.5 mm; a biocompatible surfactant; and a foam comprising a plurality of gas bubbles. Another aspect of the invention provides a slurry including: a plurality of sterile ice particles having a largest cross-sectional dimension less than about 1.5 mm; and a biocompatible excipient. Another aspect of the invention provides a slurry including: a plurality of sterile ice particles having a largest cross-sectional dimension less than about 1.5 mm; and a lipolytic agent.

Injectable slurries and methods of manufacturing and using the same

Exemplary embodiments of apparatus and method for obtaining one or more portions of biological tissue ('micrografts') to form grafts are provided. For example, a hollow tube can be inserted into tissue at a donor site, and a pin provided within the tube can facilitate controlled removal of the micrograft from the tube. Micrografts can be harvested and directly implanted into an overlying biocompatible matrix through coordinated motion of the tube and pin. A needle can be provided around the tube to facilitate a direct implantation of a micrograft into a remote recipient site or matrix. The exemplary apparatus can include a plurality of such tubes and pins for simultaneous harvesting and/or implanting of a plurality of micrografts. The harvested micrografts can have a small dimension, e.g., less than about 1 mm, which can promote healing of the donor site and/or viability of the harvested tissue.

Method and apparatus for tissue grafting and copying

An exemplary treatment system can be provided which can include a laser system configured to emit at least one laser beam, and an optical system configured to focus the laser beam(s) to a focal region at a selected distance from a surface of a tissue. The focal region can be configured to illuminate at least a portion of a target. The optical system can cause an irradiation energy transferred to the focal region of the laser beam(s) to (i) generate a plasma in a first region of the tissue adjacent to the target, and (ii) avoid a generation of a plasma in a second region of the tissue. The optical system has a numerical aperture that is in the range of about 0.5 to about 0.9. An exemplary method can also be provided to control such treatment system.

Method and apparatus for selective treatment of biological tissue

Systems and methods are provided for treating or preventing carbon monoxide poisoning. In particular, systems and methods are provided for a phototherapy treatment or prevention system that delivers light radiation to a patient's body to photodissociate carbon monoxide from hemoglobin.

System and method for phototherapy for preventing or treating carbon monoxide poisoning

The present invention provides compositions comprising energy (e.g., light) absorbing submicron particles (e.g., nanoparticles comprising a silica core and a gold shell) and methods for delivering such particles via topical application. This delivery is facilitated by application of mechanical agitation (e.g. massage), acoustic vibration in the range of 10 Hz-20 kHz, ultrasound, alternating suction and pressure, and microjets.

Compositions and methods comprising energy absorbing materials for follicular delivery

Exemplary methods and devices can be provided for harvesting a plurality of small tissue pieces, e.g., having widths less than about 1 mm or 0.5 mm, using one or more hollow needles. A fluid can be flowed through a conduit past the proximal ends of the needles to facilitate removal of the tissue pieces from the needle lumens, and can maintain the tissue pieces in a controlled and protective liquid environment. A filter can be used to extract and collect the tissue pieces from the liquid, or the tissue pieces can be deposited directly onto a porous dressing. Such tissue pieces can be used as microscopic grafts, which can be applied directly to a wound site or provided on a substrate or dressing, or stored for later use. Such microscopic grafts can promote tissue regrowth and wound healing, or can be applied to a scaffold to grow new tissue.

Method and apparatus for tissue harvesting

Exemplary embodiments of the present disclosure provide method and apparatus for facilitating stretching of a biological tissue by forming a plurality of micro-slits in the tissue. Each micro-slit can be less than about 2 mm or less than about 1.5 mm long, or even less than about 1 mm, such that small gaps that can heal quickly can be formed when the tissue is stretched. The micro-slits can be formed using a plurality of cutting arrangements or an ablative laser. The micro-slits can be formed in various patterns, including staggered rows, circular or spiral patterns, or random patterns.

Method and apparatus for tissue expansion

Cosmetic method and apparatus are provided that can provide cooling and/or freezing of skin tissue proximal to the skin surface to generate an appearance of lightening or reduced pigmentation in the skin. The skin can be cooled to a temperature of less than about &#x2212;5 degrees Celsius for a duration of about one minute or less, using a cooled surface that is at least 3 cm in width. A cooling arrangement can be provided to provide controlled heat removal from the skin tissue being treated. A sensor can optionally be provided to detect freezing of tissue proximal to the cooled surface.

Method and apparatus for cryogenic treatment of skin tissue

Growing community of inventors

Lexington, MA, United States of America

R Rox Anderson