Cara Therapeutics, Inc.

R Paul Beckett

Gary Gustafson

Janet L Ralbovsky

Ann-Marie Campbell

Tatiana Shelekhin

Carla M Gauss

Christelle Henault

Richard Foster

Robert Zhiyong Luo

Zhiyong Luo

Stephen J O'Connor

Jason S Newcom

Mary-Margaret E Zablocki

Gary R Gustafson

Tatiana E Shelekhin

The present invention provides a method of prophylaxis, treatment or inhibition of a cannabinoid receptor-associated disease, disorder or condition in a mammalian subject, the method comprising administering to the subject a compound having the structure of formula I or a pharmaceutically acceptable salt, acid salt, hydrate or stereoisomer thereof, wherein the cannabinoid receptor-associated disease, disorder or condition is pain or an inflammatory disease, disorder or condition, and wherein formula I is as follows: wherein R, R, Z, Y and m are defined in the specification.

Uses of substituted imidazoheterocycles

The present invention provides substituted imidazoheterocycles having the general structure of formula I: wherein Y is chosen from &#x2014;O&#x2014;, &#x2014;OCRR&#x2014;, &#x2014;CRRO&#x2014;, &#x2014;CRR&#x2014;, &#x2014;(CRR)&#x2014;, &#x2014;NR&#x2014;, &#x2014;CRRNR&#x2014; and &#x2014;NRCRR&#x2014;. Also provided are pharmaceutically acceptable salts, acid salts, hydrates, solvates and stereoisomers of the compounds of formula I. The compounds are useful as modulators of cannabinoid receptors and for the prophylaxis and treatment of cannabinoid receptor-associated diseases and conditions, such as pain, inflammation and pruritis.

Substituted imidazoheterocycle derivatives

The present invention provides substituted imidazoheterocyclic compounds having the structure of formula I Also provided are pharmaceutically acceptable salts, acid salts, hydrates, solvates and stereoisomers of the compounds of formula I. The compounds are useful as modulators of cannabinoid receptors and for the prophylaxis and treatment of cannabinoid receptor-associated diseases and conditions, such as pain, inflammation and pruritis.

Substituted imidazoheterocycles

Substituted imidazo[1,5-a][1,4]diazepines and imidazo[1,5-a]pyrazines as cannabinoid receptor agonists for the treatment of pain

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Yorktown Heights, NY, United States of America

R Paul Beckett