The Dow Chemical Company

Igl Pharma Inc.

Isotherapeutics Group LLC

Dow Global Technolgoies LLC

R Keith Frank

Jaime Simon

David A Wilson

Joseph R Garlich

Kenneth McMillan

Alan D Strickland

Druce K Crump

Garry E Kiefer

Dorothy L Roerden

Kelli R Jay

William Jack Kruper, Jr

Walter L Vaughn

William A Fordyce

Roberta C Cheng

Steven H Christiansen

Tipton T Masterson

Teresa Littleton

Daniel J Macey

Robert J Michalowski

William F Goeckler

Dana W Simon

This invention relates to a Kit formulation to prepare a radioactive, bone-seeking, pharmaceutical drug that has high radiochemical purity (RCP) in a fast, facile and reproducible process. The Kit has at least two vials and a two-part buffer system with instructions on how to make the drug formulation in a radiopharmacy. The drug formulations of this invention can be conveniently and reproducibly prepared with better delivery of the drug to mammals, better radiochemical purity of the formulation for use in treating a mammal having bone pain, one or more calcific tumors or needing bone marrow suppression or bone marrow ablation.

DOTMP kit formulations for radioisotopes

This invention relates to radioactive, bone-seeking, pharmaceutical compositions that are administered multiple times to a patient, have a lower impurity profile, a longer shelf life, and are less expensive to prepare.

Method of use for therapeutic bone agents

This invention concerns a pharmaceutically-acceptable composition of radioactive metals, which are used for treating various diseases in animals or humans, such as cancer and arthritis.

Radioactive compositions and methods for their therapeutic use

This invention relates to radioactive, bone-seeking, pharmaceutical methods, compositions and formulations that have a lower impurity profile, a longer shelf life, improved availability and are less expensive to prepare. The compositions of this invention can be conveniently prepared in a timely manner resulting in improved availability and delivery of the drugs to patients.

High purity therapeutic bone agents

This invention relates to medical uses of radiopharmaceuticals. Specifically, the present invention relates to the use of radiopharmaceuticals to treat osteomyelitis. The present invention provides improved system and methods of for the direct delivery of radiopharmaceuticals to the site of osteomyelitis.

Treatment of osteomyelitis with radiopharmaceuticals

The present invention concerns the use of a radioiodinated phenolic compound of the formulawherein: m and n are independently 0, 1, 2 or 3, X is a group that is negatively or positively charged at physiological pH, R, R, Rand Rare independently hydrogen, C-Calkyl, or a carboxyl group, and I* isI,I orI, and its pharmaceutically-acceptable salts. The compound is formulated and used in vivo in an animal in brachytherapy in an implantable catheter. In addition, due to the rapid renal clearance of these compounds, they may be used to study renal function. A process to prepare these compounds is also disclosed.

Radioiodinated sulfonated phenols and process therefore

A method for preventing loss of bone mineral in mammals which method comprises administering to a mammal an amount of an aminoalkylenephosphonate which is effective to prevent or minimize loss of bone material density. The aminoalkylenephophonates of the present invention should have at least one R-N(Alk-PO H ) group or at least two RRN-Alk-PO H groups wherein R and R can be, same or different, aliphatic or cyclic moiety, and Alk is an alkylene group having from 1 to 4 carbon atoms.

Aminoalkylenephosphonates for treatment of bone disorders

Actinium-225 complexes comprising functionalized polyazamacrocyclic chelant compounds are disclosed. Such complexes show improved stability and can be conjugated to a biological carrier.

Actinium-225 complexes and conjugates for targeted radiotherapy

Radioiodinated sulfonated phenols for the study of renal function

The present invention concerns the use of a radioiodinated phenolic compound of the formula

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Lake Jackson, TX, United States of America

R Keith Frank