Physical Sciences, Inc.

Memorial Sloan Kettering Cancer Center

Apv Homogenizer Group, a Division of Apv North America, Inc.

Apv Homogenizer Group, Div. of Apv North America

Apv Homogenizer Group

R Daniel Ferguson

Nicusor V Iftimia

Daniel X Hammer

Chad Bigelow

Mircea Mujat

Teoman E Ustun

William D Pandolfe

Richard R Kinney

Milind Rajadhyaksha

Ankit H Patel

Anket H Patel

Stephen Burns

A dual-modality apparatus for imaging of biological tissue includes a reflectance confocal microscopy (RCM) imaging apparatus and an optical coherence tomography (OCT) imaging apparatus. A first optical component reflects a first beam of light provided by a RCM imaging apparatus towards a sample and passes a second beam of light provided by an OCT imaging apparatus towards the sample, such that the first and second beam of lights share at least a portion of an imaging path.

Combined reflectance confocal microscopy-optical coherence tomography system for imaging of biological tissue

A method of imaging a retina of an eye includes combining an optical path of an optical coherence tomography (OCT) imager and an optical path of a line scanning laser ophthalmoscope (LSLO) imager using a system of optics. The method also includes using a single detector to switch between an OCT mode and a LSLO mode and acquiring images of the retina while switching between the OCT mode and the LSLO mode.

Hybrid spectral domain optical coherence tomography line scanning laser ophthalmoscope

An optical apparatus includes a system of optical components capable of operating in a scanning laser ophthalmoscope (SLO) mode and an optical coherence tomography (OCT) mode. The system of optical components includes a first optical module for the SLO mode, a second optical module for the OCT mode, and a first scanning device. The first optical module for the SLO mode includes a first source adapted to provide a first imaging beam for the SLO mode and a first detection device configured to receive a first signal associated with a first image of a retina of an eye. The second optical module for the OCT mode includes a second source adapted to provide a second imaging beam for the OCT mode and a second detection device configured to receive a second signal associated with a second image of the retina. The first scanning device is configured to move the first imaging beam along the retina in the slow axis of the SLO mode to acquire the first image and (ii) to move the second imaging beam along the retina in the fast axis of the OCT mode to acquire the second image.

Multi-functional adaptive optics retinal imaging

A system provides an optical image of an object. A first module tracks a reference feature of the object. A second module includes a source for an imaging beam, a scanning device to move the imaging beam along a portion of the object and a detection device receives a signal associated with an image of the portion of the object. The first module controls the position of the imaging beam relative to the reference feature to correct for the motion of the object. A third module detects a distortion of the object and compensates for the distortion.

Stabilized retinal imaging with adaptive optics

A first optical module scans a portion of an eye with a line of light, descans reflected light from the scanned portion of the eye and confocally provides output light in a line focus configuration. A detection device detects the output light and images the portion of the eye. A second optical module detects an optical distortion and corrects the optical distortion in the line of light scanned on the portion of the eye.

Adaptive optics line scanning ophthalmoscope

An apparatus for imaging an eye includes a housing and a system of optical components disposed in the housing. The apparatus is capable of operating in a line scanning laser ophthalmoscope (LSLO) mode and an optical coherence tomography (OCT) mode. The system of optical components can include a first source to provide a first beam of light for the OCT mode and a second source to provide a second beam of light for the LSLO mode. In the OCT mode, a first optic is used that (i) scans, using a first surface of the first optic, the first beam of light along a retina of an eye in a first dimension, and (ii) descans, using the first surface, a first light returning from the eye in the first dimension to a detection system in the OCT mode. In the LSLO mode, the first optic is used where the second beam of light passes through a second surface of the first optic.

An apparatus for imaging an eye includes a housing and a system of optical components disposed in the housing. The apparatus is capable of operating in a line scanning laser opthalmoscope (LSLO) mode and an optical coherence tomography (OCT) mode. The system of optical components can include a first source to provide a first beam of light for the OCT mode and a second source to provide a second beam of light for the LSLO mode. In the OCT mode, a first optic is used that (i) scans, using a first surface of the first optic, the first beam of light along a retina of an eye in a first dimension, and (ii) descans, using the first surface, a first light returning from the eye in the first dimension to a detection system in the OCT mode. In the LSLO mode, the first optic is used where the second beam of light passes through a second surface of the first optic.

Real time, high-speed image stabilization with a retinal tracking scanning laser ophthalmoscope (TSLO) enables new approaches to established diagnostics. Large frequency range (DC to 19 kHz), wide-field (40-deg) stabilized Doppler flowmetry imaging is described for human subjects. The fundus imaging method is a quasi-confocal line-scanning laser ophthalmoscope (LSLO). The retinal tracking system uses a confocal reflectometer with a closed loop optical servo system to lock onto features in the ocular fundus and automatically re-lock after blinks. By performing a slow scan with the laser line imager, frequency-resolved retinal perfusion and vascular flow images can be obtained free of eye motion artifacts.

Monitoring blood flow in the retina using a line-scanning laser ophthalmoscope

Systems and methods for providing a line-scanning laser ophthalmoscope (LSLO) are disclosed. The LSLO uses a substantially point source of light, such as an infrared laser or a super-luminescent diode. The point source is expanded to a line. The LSLO scans the line of light in a direction perpendicular to the line across a region of an eye having an undilated pupil The reflected light is received confocally, using monostatic beam geometry. A beam separator, such as a turning prism or mirror, diverts one of the incoming light and the reflected light to separate the light. An optical stop prevents non-confocally received light from reaching a one-dimensional detector, such as a linear CCD array. An electrical signal responsive to the output light at each of a plurality of locations along the line of output light is processed to provide images of the scanned portion of the eye.

Line-scan laser ophthalmoscope

Apparatus and methods for tracking a feature on a target surface and continually providing analog corrections to tracking mirrors in real time by utilizing a low-power incoherent tracking beam to detect the movements of a reference feature on the target and confocal reflectometry to monitor the reflection from the tracking beam's current position are described. The apparatus includes a dithering device for dithering the tracking beam in a first and a second direction with an oscillatory motion, a tracking device for controlling the position of a therapeutic beam relative to a target and for controlling the position of the tracking beam relative to a reference feature, a reflectometer for providing an output signal with a phase corresponding to a phase of the reflected tracking beam, and a signal processor for comparing the phase of the reflectometer output signal to the phases of the oscillatory motion and for controlling the tracking device so that the therapeutic beam to tracks relative to the reference feature.

Servo tracking system utilizing phase-sensitive detection of reflectance

An homogenization valve design yields improved homogenization efficiency. The length of the valve surface relative to the valve seat or land is controlled so that the overlap is limited. This allows convergence between turbulent mixing layers and a homogenization zone. Preferably some overlap is provided, however, to contribute to the stability of the valves and avoid destructive chattering.

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Melrose, MA, United States of America

R Daniel Ferguson