Sanofi Pasteur Inc.

Aventis Pasteur S.a.

B Cell Design Sas

B Cell Design

Régis Sodoyer

Isabelle Legastelois

Raphaëlle Claude El Habib

Michel Chevalier

Armelle Cuvillier

Tino Krell

Christiane Moog

Florence Boudet

Denis Speck

Nicolas Chaudet

Isabelle Peubez

The present invention relates to polymerized recombinant proteins, to recombinant nucleic acids coding for the polymerized recombinant proteins, to expression cassettes comprising the recombinant nucleic acids, to host cells transformed by the expression cassettes and to a method for multimerizing a recombinant protein. The polymerized proteins of the invention may be used in pharmaceutical or immunogenic compositions. In particular, the recombinant proteins may be antigens, antibodies or scaffolds. In particular, the polymerized recombinant protein may be an influenza haemagglutinin.

Multimerization of recombinant protein by fusion to a sequence from lamprey

A new non-HIV vaccine antigen fromsp. permease capable of inducing a mucosal neutralizing protective antibody response against HIV infection, a neutralizing antibody directed to said antigen, and a method for the identification of new antigens from the mucosal microbiota for the development of vaccines against pathogens.

Non-HIV vaccine antigen from the vaginal microbiota capable of inducing a mucosal neutralizing protective antibody response against HIV infection

The present invention relates to a method for inducing antibodies neutralizing HIV primary isolates in a mammal, comprising administration of a pharmaceutical composition comprising a polypeptide represented by the formula N-L-C, in which:

Methods for inducing HIV-neutralizing antibodies

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Saint Genis les Ollieres, France

Régis Sodoyer