University of California

Other

Quyen T Nguyen

Roger Y Tsien

Mike Whitney

Tao Jiang

Stephen R Adams

Emilia S Olson

Dina Hingorani

Michael A Whitney

Todd Aguilera

Paul Steinbach

The present invention provides methods for guiding preservation of human neurons or human nerves during surgery by administering a fluorescently-labeled peptide that specifically binds to the human neurons or human nerves. The invention further provides human neuron or nerve targeting molecules comprising fluorescently-labeled peptides that specifically bind to human neurons or human nerves and compositions thereof.

Optimized peptides for targeting human nerves and their use in image guided surgery, diagnostic and therapeutic delivery

Optimized peptides for targeting human nerves and their use in image guided surgery, diagnostics and therapeutic

Disclosed herein, in certain embodiments, is a selective transport molecule with increased in vivo circulation. In some embodiments, a selective transport molecule disclosed herein has the formula (A-X-B-C)-M, wherein C is a cargo moiety; A is a peptide with a sequence comprising 5 to 9 consecutive acidic amino acids, wherein the amino acids are selected from: aspartates and glutamates; B is a peptide with a sequence comprising 5 to 20 consecutive basic amino acids; X is a linker; and M is a macromolecular carrier.

Peptides whose uptake in cells is controllable

Optimized peptides for targeting human nerves and their use in image guided surgery, diagnostics and therapeutic delivery

Disclosed herein, the invention pertains to methods and compositions that find use in diagnostic, prognostic and characterization of neoplasia samples based on the ability of a neoplasia sample to cleave a MTS molecule of the present invention. In some embodiments, a MTS molecule disclosed herein has the formula (A-X-B-C), wherein A is a peptide with a sequence comprising 5 to 9 consecutive acidic amino acids, wherein the amino acids are selected from: aspartates and glutamates; B is a peptide with a sequence comprising 5 to 20 consecutive basic amino acids; X is a linker; and C is a detectable moiety.

Personalized protease assay to measure protease activity in neoplasms

Imaging systems for fluorescence guided surgery are provided. An imaging system comprises a light source unit for providing one or more illumination and excitation lights to a target, a detection unit for detecting reflectance and fluorescence from the target, an optical train for directing the one or more illumination and excitation lights from the light source unit to the target and for directing the reflectance and fluorescence from the target to the detection unit, and a control unit for controlling the light source unit and the detection unit. Imaging methods for fluorescence guided surgery are also provided.

Imaging system and method for fluorescence guided surgery

Disclosed herein, in certain embodiments, is a selective transport molecule with increased in vivo circulation. In some embodiments, a selective transport molecule disclosed herein has the formula (A-X-B-C)n-M, wherein C is a cargo moiety; A is a peptide with a sequence comprising 5 to 9 consecutive acidic amino acids, wherein the amino acids are selected from: aspartates and glutatmates; B is a peptide with a sequence comprising 5 to 20 consecutive basic amino acids; X is a linker; and M is a macromolecular carrier.

A single section lift-up technique for eyelash extensions with curved tweezers. Place three pieces of surgical tape over upper natural eyelashes to divide the eyelid into an outer corner, a middle and an inner corner section. Lift up the upper eyelashes one at a time from under the surgical tape on each section with a curved tweezers. Attach adhesive coated false eyelashes one at a time against the upper lashes of the each section with the curved tweezers. Attach adhesive coded false eyelashes one at a time against the upper eyelashes of each section with the curved tweezers.

Single section lift-up technique for eyelash extensions

The present invention provides methods for guiding preservation of neurons or nerves during surgery by administering a fluorescently-labeled peptide or aptamer that specifically binds to the neurons or nerves. The invention further provides targeting molecules of fluorescently-labeled peptides or aptamers that specifically bind to neurons or nerves and for compositions thereof.

Peptides and aptamers for targeting of neuron or nerves

Interlocked two V-shaped two strands eyelashes

V-shaped two strands eyelash for adhesive interlocking

A method to apply a V-shaped eyelash having four symmetric tapered strands attached at the mounting portion to natural eyelash's hair. The V-shaped eyelash has two strands on each side. The V flare corresponds to an angle can be less than or equal to 160&#xb0; degrees. The thickness of each strand can be 0.10 mm to 0.30 mm thick at the base and tapered at the tips. The lengths can be from 7 mm to 17 mm giving the illusion of a natural long, beautiful and luscious eyelash. Because the eyelash extension is a V shape with the two strands on each side, the eyelash can distribute weight evenly on each side. The natural hair strand as the holder at center also making the eyelash extensions last longer. The eyelashes are made from synthetic fiber which is crimp free and can be permed to a C, and J curl.

Growing community of inventors

La Jolla, CA, United States of America

Quyen T Nguyen