Xenoport, Inc.

Glaxo Group Limited

Sb Pharmco Puerto Rico Inc.

Smithkline Beechman Cork Limited

Qunying Dai

Suresh Kumar Manthati

Stephen P Raillard

Philip C Dell'Orco

David H Igo

Lee M Katrincic

Li-Jen Ping

Hao Yin

Claire Hisler

Peng Liu

Pingyun Y Chen

Clifford S Labaw

Paul G Spoors

Christopher S Brook

Wei Chen

Choon K Oh

Christopher Werner

Ann Marie Diederich

Jun Wang

The present disclosure relates to methods of synthesizing 1-(acyloxy)-alkyl carbamate prodrugs and to intermediates used in the methods.

Methods of synthesizing 1-(acyloxy)-alkyl carbamate prodrugs

The present disclosure relates to methods of synthesizing N-hydroxysuccinimidyl-carbonate intermediates from the corresponding sulfones useful in the preparation of 1-(acyloxy)-alkyl carbamate prodrugs.

[object Object]

The present invention relates to a salt of carvedilol and/or corresponding solvates thereof, compositions containing such carvedilol and/or corresponding solvates thereof, and/or methods of using the aforementioned compound(s) in the treatment of certain disease states in mammals, in particular man. The present invention further relates to carvedilol phosphate salts, and/or solvates thereof, which include a novel crystalline form of carvedilol dihydrogen phosphate (i.e., which is the dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy)ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate, etc.) and/or other corresponding solvates thereof, compositions containing these carvedilol phosphate salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.

Carvedilol salts, corresponding compositions, methods of delivery and/or treatment

The present invention relates to a salt of carvedilol, corresponding compositions containing such a carvedilol salt or corresponding solvates thereof, and/or methods of using the aforementioned compound(s) in the treatment of certain disease states in mammals, in particular man. The present invention further relates to a novel crystalline form of carvedilol hydrobromide, which is the hydrobromide salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy)ethyl]amino]-2-propanol, and/or other carvedilol solvates thereof, compositions containing salts or solvates of carvedilol hydrobromide, and methods of using the aforementioned compound(s) to treat hypertension, congestive heart failure, and angina, etc.

Carvedilol hydrobromide

Growing community of inventors

King of Prussia, PA, United States of America

Qunying Dai