Js Innopharm (shanghai) Ltd.

Chinese Academy of Sciences

Shanghai Sim-bcd Semiconductor Manufacturing Co., Ltd.

Shanghai Institutes for Biological Sciences, Cas

Shanghai De Novo Pharmatech Co., Ltd.

Qun Li

Wen Kang Xu

Jintao Zhang

Shanzhong Jian

Zuhua He

Ao Qiong Li

Daxin Gao

Zhimin Hu

Lei Cheng

Junelei Li

Yingying Zhang

Ertao Wang

Disclosed herein are compounds of formula I and/or a stereoisomer, stable isotopologue, and/or pharmaceutically acceptable salts thereof; and therapeutic uses of these compounds, which are inhibitors of tryptophan 2, 3-dioxygenase 2 (TDO2) and/or indoleamine 2, 3-dioxygenase 1 (IDO1), potentially useful in the treatment of diseases treatable, such as cancers. 

Heterocyclic compounds, compositions comprising heterocyclic compound, and methods of use thereof

(I) Disclosed herein are compounds of formula I, and/or a stereoisomer, a stable isotope, or a pharmaceutically acceptable salt thereof; and therapeutic uses of these compounds, which are kinase inhibitors potentially useful in the treatment of diseases treatable, such as cancers, as well as pharmaceutical compositions, comprising a compound of formula I, and/or a stereoisomer, a stable isotope, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. 

Heterocyclic compounds as kinase inhibitors, compositions comprising the heterocyclic compound, and methods of use thereof

This disclosure is related to a fused-ring compound of formula (I) and/or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the fused ring compound of formula (I) and/or a pharmaceutically acceptable salt thereof, preparation methods thereof, and use thereof in modulating activity of indoleamine 2, 3-dioxygenase (IDO) and/or tryptophan 2, 3-dioxygenase (TDO). This disclosure further provides methods of treating IDO and/or TDO-associated diseases, including cancer, viral infection and autoimmune diseases. 

Fused-ring compounds, pharmaceutical composition and uses thereof

A switch mode power supply (SMPS) includes a buck converter circuit that includes a first inductor coupled to an output terminal and a switch device coupled the first inductor. A controller is configured for regulating the output current based at least in part on controlling a peak current in the first inductor according to a ratio between an instantaneous voltage to an average voltage at the negative output terminal. The controller is configured to cause the SMPS to operate in a boundary conduction mode (BCM). The controller is configured to maintain a constant average output current that is substantially independent of the input voltage and the output voltage, and also provide a high power factor.

Method and circuit for constant current buck converter

Provided are a crop height regulatory gene from, expression regulatory sequences thereof and uses thereof. The crop regulatory gene can be used to regulate the plant height, volume, tiller, yield, flower organ size, or seed size of crops.

Plant height regulatory gene and uses thereof

A novel crop grain filling gene (GIF1) and the applications thereof are presented in the invention. The GIF1 gene can be applied to control grain filling, enhance crop yield or quality, or improve disease resistance or storage stability of crop grains. A method for improving crops is also presented in the invention. The GIF1 gene shows valuable potentials in controlling crop yield, quality, storage, and resistance to diseases.

Growing community of inventors

Shanghai, China

Qun Li