Shanghai Institute of Pharmaceutical Industry

China State Institute of Pharmaceutical Industry

Shanghai Bioenergy Medicine Science & Technology Co., Ltd.

Nanjing Bioenergy Medicine Science & Technology Co., Ltd.

Js Innopharm (shanhai) Ltd.

Shanghai Kairun Biology Medicine Limited Liability Company

Harbin Hongdoushan Bio-pharm Co., Ltd.

Heilongjiang Hongdoushan Pharmaceutical Co., Ltd.

Shanghai Modern Pharmaceutical Co., Ltd.

Suzhou Ji Er Biological Medicine Co. Ltd.

Fudan University

Zhejiang Hisun Pharmaceutical Co., Ltd.

Js Innopharm Ltd.

Quanhai Liu

Jun Zhang

Wei Zhou

Minyu Liu

Ying Liu

Yu Shen

Zhen Zhang

Li Cai

Yan Qin

Renhai Chen

Lin Xiao

Yuqiong Dong

Haiyan Sun

Zhiru Xu

Chungang Li

Yan Li

Bin Zhou

Hua Bai

Tong Wu

Wei Wu

Pei Zhou

Xuejun Wu

Xiaoling Huang

Yifang Deng

Wentao Cai

Jun Lin

Michael James Newman

Guoping Wang

Jintao Zhang

Guobin Ren

Jinyao Chen

Yongzhi Shu

Jian Hou

Lin Yao

Haifeng Hu

Shuai Zhao

Shenrong Tang

Min-yu Liu

Liling Jin

Meiqing Feng

Tian Zhang

Zhenpeng Yu

Gouping Wang

Mianli Pan

Pengxia Yu

Baoquan Zhu

Zhiguo Wang

Xuehai Wu

Xiangduan Tan

Jingjing Li

Moli Hua

Jingyue Xu

The invention discloses a panaxadiol glycoside derivative and a preparation method and application thereof. Such compounds show strong anti-inflammatory effects in vitro and in animal model experiments, and thus can be used to prepare anti-inflammatory drugs, especially can be used for treating asthma and COPD. In the experiment, the above-mentioned compounds have obvious effects on asthma and COPD, and the efficacy of the high-dose group is superior than that of dexamethasone and budesonide. Even under the dose much exceeding the therapeutic dose, no obvious affect on blood routine and blood glucoseis observed. It has high industrial prospects in the field of anti-inflammatory drugs, especially in the field for treating asthma and COPD.

Panaxadiol glycoside derivative and preparation method and application thereof

Disclosed are a compound represented by Formula I or a pharmaceutically acceptable salt thereof, a preparation method therefor, the Formula I, and an application thereof in preparing drugs for regulating blood lipids. 

Acetophenone compound, preparation method therefor, and application thereof in blood lipid regulation

Disclosed is a compound represented by formula I or a pharmaceutically acceptable salt thereof, preparation method thereof, and use thereof in preventing or treating fatty liver or in preparing pharmaceuticals for weight loss. 

Acetophenone compound, preparation method thereof, and application thereof in fatty liver prevention and treatment

Disclosed are amide compounds, preparation method and uses thereof, specifically, the compounds represented by formula I or pharmaceutically acceptable salts, wherein R, R, R, R, R, Q, X and n are defined as in the description. Also disclosed are a method for preparing the compounds of formula I, a composition containing the compounds, and the uses of the same in the preparation of medicaments for regulating blood lipid and/or preventing gallstone. The compounds of formula I disclosed in the present invention have stability in vitro, good solubility in the pharmaceutical organic solvents and favorable bioavailability in animals.

Amide compound, preparation method and uses thereof

Disclosed herein is a method of treating psoriasis involving the use of compound of formula I and/or a pharmaceutically acceptable salt thereof. 

Heterocyclic compounds for treating psoriasis

Disclosed are a platinum (II) compound, a preparation method therefor, and a pharmaceutical composition and an application thereof. The preparation method comprises the following steps: enabling dihydrate diammine platinum nitrate (4) to react with the carboxylate ligand derivative (5) in water, to produce a platinum (II) compound. Also provided are an application of the platinum (II) compound in preparation of an antitumor drug, and a pharmaceutical composition. The pharmaceutical composition contains an active component and a medicinal carrier, the active component containing the platinum (II) compound, and the mass percentage of the active component being 0.1%-95%. The platinum (II) compound of the present invention is well water-soluble, low toxic, easily prepared, and efficient in antitumor activity. 

Platinum (II) compound, preparation method therefor, and pharmaceutical composition and application thereof

The present invention discloses an application of depolymerized holothurian glycosaminoglycans (DHG) in preparation of a drug for the prevention and treatment of thromboembolic diseases. The DHG is more than one type of DHG with weight-average molecular weights between 26,000 and 45,000 Da. When being intravenously or subcutaneously injected, the drug using the DHG with weight-average molecular weights between 26,000 and 45,000 Da as an active ingredient has a significant anticoagulant effect, while at the same time, has little side effects, and is effective for use in the prevention and treatment of the thromboembolic diseases. For an injection of DHG with weight-average molecular weights between 26,000 Da and 45,000 Da, the blood coagulation time is prolonged and the anticoagulant effect is enhanced as the dosage increases; the subcutaneous administration is used and is more favorable for use in the drug, and the convenience and safety of use the drug are improved.

Application of depolymerized holothurian glycosaminoglycans (DHG) in preparation of drug for prevention and treatment of thromboembolic diseases

An amorphous asiatic tromethamine salt and the preparation method thereof. The method includes the steps of: (1) dissolving asiatic acid in an organic solvent; step (2) mixing with tromethamine; step (3) stirring and salifying the same, and then removing the organic solvent. The method for preparing the amorphous asiatic tromethamine salt is easy and effective, and the water solubility and bioavailability of the asiatic tromethamine salt thus obtained are greatly compared with the prior art.

Amorphous asiatic tromethamine salt and preparation method thereof

A highly pure asiaticoside and a pharmaceutical grade asiatic acid can be prepared, along with salts of asiatic acid, for use in formulating therapeutic compositions that are suitable for treating arthritis, psoriasis and other inflammatory diseases, as well as pulmonary fibrosis, diabetic nephropathy, and other fibrotic diseases.

Therapeutic formulations based on asiatic acid and selected salts thereof

The invention discloses a dithiolopyrrolone compound represented by formula I or its pharmaceutically acceptable salts, wherein X, R, R, R, Rare defined as in the description. The invention also discloses the preparation of such compounds, and the use of such compounds in preparation of medicaments for increasing peripheral white blood cells and in preparation of ancillary medicaments for inhibiting the decrease of peripheral white blood cells in radiotherapy or chemotherapy.

Dithiolopyrrolone compounds, the preparation and the use thereof

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Shanghai, China

Quanhai Liu