Endovasix, Inc.

Target Therapeutics, Inc.

Pathwork Diagnostics, Inc.

Quang Q Tran

Victor C Esch

Marc-Alan Levine

Stephen J Hebert

Eduardo U Sucgang

R Rox Anderson

Henry Nita

Paul C Slaikeu

Glenda G Anderson

Marlowe E Patterson

Estela D Gatchalian

Alejandrina Pattin

Cheryl Kay Hornbaker

Methods, computer systems, and computer readable medium for testing a plurality of models in order to classify a biological specimen. A determination is made as to whether a model precondition associated with a model in the plurality of models has been satisfied. The model is skipped when the model precondition has not been satisfied. When the model precondition has been satisfied, the first model is tested by selecting a calculation from the first model. The selected calculation is computed using cellular constituent abundance values from the biological specimen in accordance with a calculation algorithm set forth in the selected model. This selecting and computing is repeated for one or more calculations in the selected model. Then, each of these calculations is aggregated in accordance with an aggregation algorithm associated with the selected model. These steps are repeated for at least one other model in the plurality of models. A computer medium comprising a classifier for classifying a biological specimen into a biological sample class that includes one or more models. Each of the one or more models comprises (i) an optional model precondition, (ii) a calculation algorithm, (iii) a plurality of calculations, and (iv) a calculation aggregation algorithm.

Knowledge-based storage of diagnostic models

Methods and apparatus for creating fluid flow from one location to another are disclosed. The fluid flow is created via the absorption of repetitive pulses of radiation in a fluid to generate bubbles that expand and collapse repetitively. This fluid mechanism, or pumping phenomenon, can be used to aid removal of a total or partial occlusion in a body passage by disrupting a surface of the occlusion with acoustic shock and pressure waves and/or by causing mechanical disruption of the occlusive material. Appropriate selection of materials and particular constructions improve apparatus flexibility.

Flexible flow apparatus and method for the disruption of occlusions

The invention encompasses methods and apparatus for pumping fluid from one location to another through the repetitive expansion and collapse of bubbles generated as a result of the absorption of repetitive pulses of radiation in a fluid. This pumping phenomenon can be used to aid removal of a total or partial occlusion in a body passage by emulsifying the occlusion with acoustic shock and pressure waves or by causing mechanically disrupting the occlusive material.

Flow apparatus for the disruption of occlusions

This invention is to a minimally invasive surgical device. In particular, the invention relates to an infusion catheter which may be used in cardiovascular and endovascular procedures to deliver diagnostic, therapeutic, or vasoocclusive agents to a target site accessible through the vasculature. The device is a flow-directed infusion catheter having a variety of sections of different flexibilities with tapered junctions between those sections. The inventive catheter is directed to that target site by a flow of blood to the site.

Flow-directed catheter

Apparatus for pumping fluid from one location to another via generation of bubbles in fluid, and expansion and callapse thereof, are described. These apparatus deliver repetitive pulses of radiation to a fluid to form bubbles therein. The expansion and collapse of the bubbles cause fluid motion or pumping. This pumping can be used to facilitate removal of a total or partial occlusion in a body passage by a variety of mechanisms. The apparatus are flexible to facilitate use within a body passage.

The invention encompasses methods and apparatus for pumping fluid from one location to another through the repetitive expansion and collapse of bubbles generated as a result of the absorption of repetitive pulses of radiation in a fluid. This pumping phenomenon can be used to aid removal of a total or partial occlusion in a body passage by emulsifying the occlusion with acoustic shock and pressure waves or by mechanically disrupting the occlusive material.

Growing community of inventors

Fremont, CA, United States of America

Quang Q Tran