Chinese Academy of Sciences

Beijing Orient Institute of Measurement and Test

Shanghai Institutes of Biological Sciences, Cas

Quan Chen

Ming Wang

Lei Du

Zheng Li

Lin Nan Li

Xiaohui Wang

Haiyang Liu

Xiaojiang Hao

Hao Chai

Shujuan Song

Wenyu Cheng

Haiying Hang

Huiru Zhang

Xiaoli He

Baowei Li

Deqiang Song

Zibin He

Hao Xing

Chen Yan

Yizhou Wang

An anechoic chamber and a construction method thereof are provided, the anechoic chamber includes a top surface, being a polygon; trapezoid surfaces, corresponding to edges of top surface, upper edge lengths of trapezoid surface being equal to edge lengths of top surface, trapezoid surfaces being connected to edges of top surface through the upper edges, the trapezoid surfaces being sequentially connected along a circumferential direction of top surface, and being at angle to the top surface; rectangular surfaces, corresponding to the trapezoid surfaces, upper edge lengths of rectangular surface being equal to lower edge lengths of trapezoid surface, rectangular surfaces being connected to the trapezoid surfaces through the upper edges, the rectangular surfaces being sequentially connected along a circumferential direction of the lower edges of trapezoid surfaces, and being perpendicular to the top surface; and an absorbing material, disposed on the top surface, the trapezoid surfaces and the rectangular surfaces.

Anechoic chamber and construction method thereof

A monoclonal antibody against human PrPc protein capable of reducing the expression level of transcription factor Twist1 in a targeting mode and inducing macrophage and NK cells to target to rectal cancer tumor cells. The combined drug therapy with the antibody and cetuximab also exhibits inhibitory effect on tumor better than administration of the antibody or cetuximab alone.

Monoclonal antibody against human PrPc and use thereof

The invention relates to a derivative of 15-oxospiramilacton, particularly to a compound of Formula I or II, or an isomer, a solvate or a pharmaceutically acceptable salt thereof. The invention also relates to a pharmaceutical composition comprising the compound as pharmaceutically active ingredient, a method for preparing the same, and use thereof in manufacture of an anti-tumor agent. The derivative of 15-oxospiramilactone of the invention have an activity against multiple tumor cell lines, and the anti-tumor activity is positively correlated to an activity inhibiting the Wnt signaling pathway. 

15-oxospiramilactone derivatives, preparation method and uses thereof

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Beijing, China

Quan Chen