University of Alberta

Battelle Memorial Institute

Naeja Pharmaceutical Inc.

Qizhu Ding

Dennis D Tanner

Ronald G Micetich

Rajeshwar Singh

Mark Whittaker

James A Franz

George Thomas

Jadwiga Kaleta

Nian Zhou

Andhe V N Reddy

Pramod Kandanarachchi

This invention relates to derivatives of alpha-amino acid amides, to pharmaceutical compositions containing such compounds, and to their use in medicine as inhibitors of cysteine proteases, particularly the cathepsins. A compound of formula (I) is described or a pharmaceutically acceptable salt, hydrate or solvate thereof. Pharmaceutically acceptable salts of the compounds of this invention include the sodium, potassium, magnesium, calcium, hydrogen chloride, tartaric acid, succinic acid, fumaric acid and p-toluenesulfonic acid salts.

Cysteine protease inhibitors

The method of the present invention is a microwave bond cleavage of a first hydrocarbon compound, the first hydrocarbon compound in a liquid phase and substantially non-aqueous, to a second compound having a shorter carbon chain than the first hydrocarbon compound. The method has the steps of exposing a combination of the first hydrocarbon compound with a supported catalyst having a carrier of a non-metallic amorphous solid with at least one catalytic metal dispersed therein to microwave energy thereby converting the first hydrocarbon compound into the second hydrocarbon compound, and recovering the second hydrocarbon compound. Advantages of the present invention include use of a low cost supported catalyst at ambient temperature and pressure.

Method of microwave bond cleavage of a hydrocarbon compound in a liquid

The method of the present invention is for producing at least hydrogen from a gaseous hydrocarbon. The gaseous hydrocarbon is selected from the group consisting of methane, ethane, butane, propane and combinations thereof. The method proceeds by exposing the gaseous hydrocarbon with the supported catalyst to microwave radiation. The supported catalyst has a support of a lattice of a non-metallic amorphous solid and at least one catalytic metal having atoms interspersed throughout the lattice of the support. A preferred embodiment is a lattice of carbon with at least one catalytic metal interspersed throughout the lattice. Examples include char.

Catalytic microwave conversion of gaseous hydrocarbons

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Qizhu Ding