Shanghai Microport Medical (group) Co., Ltd.

Shanghai Microport Cardioflow Medtech Co., Ltd.

Microport Endovascular (shanghai) Co., Ltd.

Shanghai Micoport Medical (group) Co., Ltd.

Microport Neurotech (shanghai) Co., Ltd.

Microport Medical (shanghai) Co., Ltd

Shanghai Microport Endovascular Medtech (group) Co., Ltd.

Qiyi Luo

Zhirong Tang

Wei Wang

Yu Zhang

Yu Meng Li

Qing Zhu

Guoming Chen

Xiang Liu

Junfei Li

Chengyun Yue

Yan Li

Jie Zhang

Jing Wang

Peng Huang

Baozhu Gui

Haishan Wang

Mingming Wu

Zhixiu He

Juan Hou

Shaohui Chen

Hongyan Jiang

Yahong Kang

Zhenyu Yuan

Jian Li

Yu Wang

Yi Zhou

Jie Li

Zhen Wang

Bin Xia

Dan Li

Feng Huang

Honglin Nie

Yao Yao

Xiufeng Shi

Yuan Fang

Xu Cai

Zhonghua Li

Yu Li

Xi Hu

Qifeng Yu

Zhaohua Chang

Biao Li

Dawei Wang

Zhiyong Xie

Yan Hu

Yihan Wang

Hui He

Yunlei Wang

Jie Ji

Dingguo Huang

Hao Tian

Yanbin Gao

Yongfeng Zhu

Haiyong Huang

Fang Guo

Sen Wang

Cong Tian

Dadong Zhang

Bo Yi

Changsheng Wu

Changchun Wang

Juan Meng

Zhilong Li

Jianchao Han

Jianjun Li

Fengliang Zhao

Yan-bin Gao

Qiaorong Jin

Xueqin Wang

Jiaoming Dong

Yemeng Chen

Guanbiao Xu

Xiulan Cheng

Dakai Chen

Shuguo Chen

Chubo Huang

Baoai Chen

Yihao Duan

Weiwen Sheng

Xiaoyi Zhang

Huina Lu

Jiaying Zhu

Yingzhong Yao

Fan Qi

Yating Cao

Buzhong Zheng

Lu Pang

Qingru Ji

Zunzhang Ni

Yingtao Zhang

Fanghua Sun

Xiaoxiu Li

Linfei Song

Yonggang Xiang

Cheng Chen

Chengjun Le

Qingshun Xu

Yinping Fan

Chengyun Yu

Yuanshan Mu

A stent is disclosed, which includes a stent body () and a single-radiopaque component () disposed at one or each of a proximal end and a distal end of the stent body (). The stent body () is composed of rings and struts, and one part of the single-radiopaque component () is received in a receptacle () of the stent body () and another part of the single-radiopaque component () protrudes out of a surface of the stent body (). The area of the protruding part () of the single-radiopaque component () is larger than an area of the embedded part (), the presence of the protruding part () allowing the single-radiopaque component () to appear wider and thicker in a radiologic image, enhancing the radiopacity of the stent during surgery.

Stent

A left atrial appendage (LAA) closure () and a system () for delivering the LAA closure are disclosed. The LAA closure () includes supporting struts (), wherein the supporting struts () are distributed peripherally around a first hub () and extend outward, the supporting strut () bifurcates at a first position () into a left branch () and a right branch (). The left branch () of each supporting strut () and the right branch () of an adjacent supporting strut join each other at a second position () and extend distally to form a distal end. The LAA closure further includes a supporting rod () between adjacent supporting struts () which ensures stability, absence of irregular deformation and lateral slippage, of the LAA closure (). With the supporting rods () between the adjacent supporting struts (), the LAA closure () forms a dense mesh which imparts high overall strength of the LAA closure ().

Left atrial appendage closure and delivery system thereof

A stent () used for a heart valve prosthesis and the heart valve prosthesis that includes the stent () and is used for heart valve replacement. The stent is configured to support a heart valve () and includes, along a longitudinal axis, an inflow section (), an outflow section () and a transition section () between the inflow section () and the outflow section (). The stent () has a contracted delivery configuration and an expanded deployed configuration. In the expanded deployed configuration, the inflow section () defines a concave contour that is complementary to a structure of a native valve annulus. The concave contour enables self-deployment and close adherence of the stent (), thereby preventing its displacement and perivalvular leakage after implantation.

Heart valve prosthesis

A biodegradable cross-linked polymer and methods of preparing same are provided. The biodegradable cross-linked polymer is formed from a biodegradable polymeric material having two or more arms, which is a random copolymer formed of a first monomer and a second monomer different from the first monomer. The first monomer is selected from the group consisting of L-lactide, DL-lactide, glycolid, &#x3b5;-caprolactone, trimethylene carbonate, p-dioxanone, amino acid-derived polycarbonates and polyorthoesters. The second monomer is one or two selected from the group consisting of D-lactide, DL-lactide, glycolide, &#x3b5;-caprolactone, trimethyl carbonate, salicylic acid, carbonates, amino acids and derivatives thereof. The biodegradable polymeric material has a molecular weight of from 5,000 to 1,200,000 and an intrinsic viscosity of from 0.1 to 9.0 dl/g. Each of the terminal groups on the arms of the biodegradable polymeric material is selected from the group consisting of hydroxyl amino and carboxyl groups.

Biodegradable cross-linked polymer and methods of preparing the same

A dry animal-derived collagen fiber tissue material and preparation method and bioprosthesis thereof are disclosed. The preparation method includes: 1) rinsing of an animal-derived collagen fiber tissue material that has been treated with a crosslinking agent; 2) immersion of the rinsed tissue material in a non-aqueous alcoholic solution for dehydration; 3) successive immersion of the tissue material that has been dehydrated with the non-aqueous alcoholic solution in saccharide solutions of different gradients of concentrations for gradient dehydration; 4) taking out and drying of the gradient dehydrated tissue material; and 5) hermetic packaging of the dried tissue material and sterilization. The preparation method is simple and allows the use of easily-available low-cost materials, resulting in lower costs. In addition, it can reduce the toxicity caused by a residue of the aldehyde crosslinking agent. The prepared biological tissue material is pliable and tough, less prone to bending or warping, has a water content that can be well controlled and better biocompatibility due to absence of polyhydric alcohol residues.

Dry animal-derived collagen fiber tissue material and preparation method and bioprothesis thereof

A device and method for loading an implant into a delivery system are disclose which are capable of simplifying operations required in interventional surgery using the implant. The device includes a guide cap (), a guider () and a guiding tube (). The guide cap () has a conical section () and a straight or conical tube () in communication with a small open end () of the conical section, and the conical section has a large open end () that flares outward, thereby forming a flange () facing the tube (). The guider () has tapered sections () that are tapered along an axis of the guider and thus form large and small open ends (). The small open end () has a diameter greater than a diameter of the small open end () of the conical section of the guide cap (). The guide cap () and the guider () are so sized that the flange () can cover and be locked to the guider (), with an end portion of the straight or conical tube () protruding from the small open end () of the guider (). The guiding tube () is a round tube with two open ends, in which the first open end has a diameter greater than the diameter of the small open end () of the conical section of the guide cap and smaller than the diameter of the small open end () of the guider.

Device and method for loading implant into delivery system

A branched stent graft, a convey system comprising thereof and manufacturing method thereof, the branched stent graft includes a main body () and a side branch (), at least a portion of a lowermost stent section of the side branch () closest to the main body () is not stitched to the cover of the side branch from a lower end to an upper end, the at least a portion of the lowermost stent section is located on a side of the side branch corresponding to a folding direction of the side branch. After deployed, the branched stent graft has an effective supporting force at the base portion of the side branch. In addition, during the deployment of the stent, the side branch can expand to a maximal extent even when the positioning is slightly inaccurate. Further, vascular stenosis or occlusion will not be caused even when subsequent endothelialization occurs.

Branched stent graft, delivery system comprising same and method of fabricating same

An electric handle for delivering an implant is disclosed. The electric handle () includes an electric control unit (), a power-driven transmission mechanism (), a handle housing (), an outer tube anchor () and an inner tube anchor (), wherein: the electric control unit () is operatively coupled to the power-driven transmission mechanism () to actuate the power-driven transmission mechanism (); the power-driven transmission mechanism () is supported within the handle housing () and moveable together with the outer tube anchor (); the inner tube anchor () is disposed within the handle housing () and is configured to hold an inner tube () of a delivery system; and the outer tube anchor () is configured to hold an outer tube () of the delivery system and is fixed to an end of the outer tube (). A delivery system used especially for delivery of prosthetic valves is also disclosed, including an outer tube (), an inner tube (), an expandable implant () and the electric handle ().

Electric handle for implant delivery and delivery system

The present invention relates to the field of medical instruments. Specifically, a biodegradable cross-linked polymer and a manufacturing method therefor are provided. The cross-linked polymer is obtained by bonding crosslinkable reactive groups to terminal groups of a biodegradable prepolymer having two or more arms and further subjecting the prepolymer to thermal polymerization and/or light irradiation. The cross-linked polymer has an elastic modulus of 10-4,500 MPa, and a degradation rate of 3-36 months. A biodegradable vascular stent and a preparation method therefor are also provided. The vascular stent is formed by laser cutting of polymeric tubing having a three-dimensional cross-linked network structure. The vascular stent has ample mechanical strength, a high elastic modulus at body temperature, and a regulatable degradation rate.

Biodegradable cross-linked polymer, vascular stent and manufacturing methods therefor

A degradable polyester stent is disclosed, which includes a polyester composite, wherein the polyester composite is produced from a biodegradable polyester and a metal-based material. A method of preparing the degradable polyester stent is also disclosed. The method can improve the mechanical properties of the biodegradable copolymer stent and can achieve the radiopacity of the main body and the overall of the stent.

Degradable polyester stent and preparation method thereof

An interventional medical device and manufacturing method thereof. The interventional medical device comprises: a stent body (); a surface of the stent body () being provided with a drug releasing structure (), and drug in the drug releasing structure () being drug for suppressing proliferation of adventitial fibroblasts and a drug for suppressing proliferation of intimal and/or smooth muscle cells. In use, after interventional medical device is implanted into a human body, the drug for suppressing proliferation of adventitial fibroblasts carried thereon can promote the compensatory expansion of the vessel, and the drug for suppressing proliferation of intimal cells and/or smooth muscle cells carried thereon can suppress intimal proliferation of the vessel. The combination of the two kinds of drugs greatly reduces the occurrence rate of in-stent restenosis.

Interventional medical device and manufacturing method thereof

A method for loading a medical appliance with a medicament and/or a polymer is disclosed, the medical appliance comprising one or more grooves or holes loaded with the medicament and/or polymer. The method comprising the steps of: 1) capturing an image of the grooves or holes of the medical appliance, wherein the image contains at least one complete pattern of the grooves or holes; 2) performing digital image processing on the captured image to obtain the pattern of the grooves or holes; 3) calculating a central position of the pattern of the grooves or holes, and determining an actual central position of the grooves or holes based on the central position; 4) adjusting a relative position of a loading device to the medical appliance to align an outlet of the loading device with the actual central position of the grooves or holes; and 5) opening the outlet of the loading device to load the grooves or holes. A device for loading a medical appliance with a medicament and/or a polymer is further disclosed.

Method and device for loading medical appliance with drugs and/or polymers

A stent for a bifurcated vessel includes a stent body () with two open ends (). The stent body () includes multiple sets of annular units () having multiple undulating rods () and connecting rods () positioned between adjacent annular units () and used to connect the adjacent annular units (). At least one open end () of the stent body () has a slope structure.

Stent for bifurcated vessel

The present invention discloses an interventional medical device and methods of making the same. At least one coating layer is disposed on the outer surface of the interventional medical device and the material of the outmost layer of the coating layer is a sulfonate group-containing polymer. In the present invention, the material of the outmost layer of the interventional medical device is a sulfonate group-containing polymer. The polymer is endowed with a same surface property as that of heparin in addition to appropriate hydrophilicity due to the presence of the sulfonate group. After the interventional medical device is implanted into the human body, a hydrophilic surface is formed on the outer surface of the interventional medical device which is also negatively charged in the body fluid. Therefore, cells can easily adhere and grow on the outer surface thereof as a result of the enhanced cell compatibility. Furthermore, due to a surface property that is the same as that of heparin, the material is provided with excellent anticoagulant properties which inhibit the thrombosis and lower down the incidence rate of post-operational complications.

Intervention medical device and preparation thereof

A method and a device for loading a medical appliance with a medicament and/or polymer includes capturing images of a plurality of grooves or holes of the medical appliance using an image capturing device; performing digital image processing on the image of each of the grooves or holes to obtain a pattern of each of the grooves or holes; calculating a central position of the pattern of each of the grooves or holes, and determining a loading position of each of the grooves or holes based on the central position; and adjusting a relative position between a loading device and the medical appliance to align an outlet of the loading device with the loading position of the medical appliance, and loading each of the grooves or holes with the medicament and/or polymer. The method and device can load the medical appliance with the medicament and/or polymer fast and efficiently.

Method and device for loading medical appliance with medicaments and/or polymers

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Shanghai, China

Qiyi Luo