Katholieke Universiteit Leuven, Ku Leuven R&d

Ucb Biopharma Sprl

Other

Ucb Pharma, S.a.

Ucbbiopharma Srl

Qiuya Huang

Bart Vanderhoydonck

James Thomas Reuberson

Daniel James Ford

Judi Charlotte Neuss

Helen Tracey Horsley

Anant Ramrao Ghawalkar

Richard Jeremy Franklin

Jean Herman

Thierry Louat

Daniel Christopher Brookings

Piet Herdewijn

Claire Louise Kulisa

Mark Waer

A series of pyrazolo[3,4-d]pyrimidine derivatives that are substituted at the 4-position by a diaza monocyclic, bridged bicyclic or spirocyclic moiety, are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases and malaria; and organ and cell transplant rejection.

Therapeutically active pyrazolo-pyrimidine derivatives

A series of fused bicyclic heteroaromatic derivatives of formula (I), as defined herein, being selective inhibitors of phosphatidylinositol-4-kinase III&#x3b2; (PI4KIII&#x3b2;) activity, are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases and malaria; and organ and cell transplant rejection. 

Fused bicyclic heteroaromatic derivatives as kinase inhibitors

A series of fused bicyclic heteroaromatic derivatives of formula (IA) or (IB), as defined herein, being selective inhibitors of phosphatidylinositol-4-kinase III&#x3b2; (PI4KIII&#x3b2;) activity, are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases and malaria; and organ and cell transplant rejection.

Compounds that bind to phosphatidylinositol-4-kinase III&#x3b2; (PI4KIII&#x3b2;) and inhibit the binding of PI4KIII&#x3b2; to its substrate and/or inhibit PI4KIII&#x3b2; activity may be used in the treatment and/or prevention of an autoimmune or inflammatory disorder, or organ or cell transplant rejection. A new assay for identifying compounds for use in treating and/or preventing those pathological conditions, which comprises measuring the inhibition of PI4KIII&#x3b2; activity, is also disclosed.

Autoimmune and inflammatory disorder therapy

A series of monocyclic or bicyclic diamine-substituted thieno[2,3-d]pyrimidine and isothiazolo[5,4-d]pyrimidine derivatives are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases; and organ and cell transplant rejection.

Therapeutically active fused pyrimidine derivatives

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Leuven, Belgium

Qiuya Huang