Jiangnan University

Qiuxiang Zhang

Hao Zhang

Gang Wang

Jianxin Zhao

Fengwei Tian

Daming Fan

Xiaoming Liu

Qixiao Zhai

Wenwei Lu

Yuanda Song

Feifei Chi

Min Guo

Wenli Huang

Wanqing Xu

Wei Chen

The present disclosure discloses a strain ofcapable of preventing and/or treating periodontitis and an application thereof, belonging to the field of microbiology technology. The present disclosure has screened to obtain a strain ofCCFM1139. TheCCFM1139 can alleviate periodontitis by inhibiting formation of mixed bacterial biofilms ofand, thereby reducing the amount of biofilm by 52.45%, and can reduce the content of TNF-α from 131.37 pg/mL to 83.31 pg/mL and IL-8 from 147.70 pg/mL to 121.12 pg/mL in a periodontitis cell model, reduce colonization of theand thein the oral cavity by 1-2 orders of magnitude, and reduce the amount of the alveolar bone resorption from 1838.0 μm to 805.7 μm.

Strain of lactobacillus fermentum capable of preventing and/or treating periodontitis and application

An anti-oxidativeCCFM1107 can relieve chronic alcoholic liver injury, andCCFM1107 can be used in preparing dairy products as starter culture. The dairy products of this invention include milk, milk powder, milk capsules or fermented milk containingCCFM1107. It has strong abilities of anti-oxidation, scavenging diphenyl picrylhydrazyl (DPPH) radical and hydroxyl radical, inhibiting lipid peroxidation, tolerating cholate, chlorine sodium and pH, and can improve liver function and antioxidative index, lower serum endotoxin level and regulate intestinal flora distribution, thus effectively relieving alcoholic liver injury of mice.

[object Object]

The invention provides a novel strain of cadmium-removingbacterium, CCFM8610, which has a good tolerance to acidic environments.CCFM8610 has a good tolerance to cadmium-containing medium and can effectively bind cadmium in vitro. Animal studies have shown that it can effectively reduce tissue cadmium accumulation and facilitate fecal cadmium excretion.CCFM8610 has a great potential to be used as an active ingredient in cadmium-removing pharmaceutical drugs and fermented foods.

TheCCFM8661 is tolerant to acid and lead ions in vitro which can tolerate lead ions solution with the initial concentration of 150 mg/L, and has a strong capability of binding lead ions, which can reduce the lead level in mice blood, liver, kidney and stomach, significantly improve antioxidant indicators and alleviate pathological symptoms of lead exposed mice.

Protective effects and application of a lactobacillus plantarum on the alleviation of lead toxicity

Growing community of inventors

Wuxi, China

Qiuxiang Zhang