Shanghai Jiaotong University

Nippon Chemical Industrial Co., Ltd.

Qiupeng Hu

Wanbin Zhang

Zhenfeng Zhang

A method for preparing chiral &#x3b3;-secondary amino alcohol includes: adding into a solvent an acid addition salt of &#x3b2;-secondary amino ketone represented by general formula (1), an alkali, a metal salt additive and a diphosphine-rhodium complex, so as to carry out a reaction in a hydrogen atmosphere and obtain a chiral &#x3b3;-secondary amino alcohol compound represented by general formula (2). In general formula (2), Ar represents an aryl group with or without substituent group(s), R represents an alkyl group or an aralkyl group, and HY represents an acid. The synthesis scheme has a simple process, the metal salt additive remarkably improves the effect of a rhodium-catalyzed asymmetric hydrogenation technology, and accordingly, the reaction yield and the optical purity of a product are improved, the production process is simplified, production costs are reduced, and the synthesis scheme is highly suitable for mass industrial production. 

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Shanghai, China

Qiupeng Hu