Radiometer Medical Aps

Turun Yliopisto

Qiu-Ping Qin

Harri Takalo

Kim Pettersson

Allan Milton Byrnard

Kirsten Marie Jakobsen

Substrates for thrombin and assays for determining the level of bioactive thrombin in a sample are disclosed, wherein the substrate has the general formula: A-X&#x2014;Z-A' wherein one of either A or A&#x2032; comprises a luminescent chelate and the other one of A or A&#x2032; comprises a first partner of a binding pair, X forms a tri- or tetra-peptide, and Z comprises a linker.

Thrombin substrate and assay for determining the level of bioactive thrombin in a sample

A bioaffinity assay for quantitative determination in a sample of free PAPP-A, defined as the pregnancy associated plasma protein A (PAPP-A) that is not complexed to the proform of major basic protein (proMBP), where free PAPP-A is determined either i) as a calculated difference between measured total PAPP-A and measured PAPP-A complexed to proMBP, or ii) by a direct bioaffinity assay measuring only free PAPP-A. Also disclosed is a method for diagnosing an acute coronary syndrome in a person by using as marker either free PAPP-A as such or a ratio free PAPP-A/total PAPP-A, free PAPP-A/PAPP-A complexed to proMBP, or PAPP-A complexed to proMBP/total PAPP-A.

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Turku, Finland

Qiu-Ping Qin