Guangzhou Joyo Pharmatech Co., Ltd.

Cspc Zhongqi Pharmaceuticall Technology (Shijiazhuang) Co., Ltd.

Zhejiang Longcharm Bio-Tech Pharma. Co., Ltd.

Cspc Zhongqi Pharmaceutical Technology Co., Ltd.

Qiu Li

Jian Li

Shuhui Chen

Jikui Sun

Peng Li

Jie Li

Wentao Wu

Tao Feng

Zhengxia Chen

Jianfei Wang

Yangyang Xu

Yikai Wang

Guangwen Yang

Linlin Chen

Kaijun Geng

Rongxin Huang

Zhihua Ao

Deyao Li

Disclosed are a class of compounds having a highly selective inhibition of ROS1, and the use thereof in the preparation of drugs for treating diseases related to abnormal ROS1 kinase expression. Specifically disclosed are compounds represented by formula (IV) and a pharmaceutically acceptable salt thereof.

Compound as highly selective ROS1 inhibitor and use thereof

Disclosed are a pyrrolopyrimidine compound and a use thereof in preparing a medicine for diseases related to a BTK protein kinase inhibitor. Specially, disclosed are a compound as shown in formula (III) and a pharmaceutically acceptable salt thereof.

Pyrrolopyrimidine compound as BTK inhibitor and use thereof

Provided is a FGFR inhibitor, designating a compound represented by formula (I) or a pharmaceutically acceptable salt thereof. Also provided is the application of a drug for treating solid tumors, such as FGFR related diseases. 

Substituted pyrrolo[2,1-f][1,2,4]triazines as FGFR inhibitors

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Qiu Li