University of Central Florida Research Foundation, Inc.

Qiu Dai

Qun Huo

Xiong Liu

Disclosed herein are systems and methods for detecting Chemical Species, Biomolecules and Biotargets (Analytes) using receptor functionalized metal nanoparticles and Dynamic Light Scattering.

Detection of analytes using metal nanoparticle probes and dynamic light scattering

Detection of analtyes using metal nanoparticle probes and dynamic light scattering

An ultra sensitive method for detection of biomolecules includes the step of providing a plurality of bioreceptor functionalized nanoparticle probes. The nanoparticles can include metal, semiconductor, radioactive isotope or fluorescent dye molecules. A sample solution suspected of including the target is contacted with the probes, wherein if present, the target binds to the bioreceptor. After such binding a separating step follows. In the separating step, probes having the target bound thereto are separated from probes not having the target bound thereto. In one embodiment probes having the target bound thereto are then decomposed to generate ions, or broken into discrete radioactive isotopes or fluorescent dye molecules to form a solution including a large plurality of metal ions, radioactive isotopes or dye molecules. A concentration of ions, radioactive isotopes, or dye molecules in the solution is then determined and using this information the concentration of the target in the original sample solution is determined.

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San Jose, CA, United States of America

Qiu Dai