Nantbio, Inc.

Nantbioscience, Inc.

Nant Holdingsip, LLC

Abraxis Bioscience, LLC

California Capital Equity, LLC

Qinwei Wang

Chunlin Tao

David G Ho

Laxman Nallan

Tulay Polat

Patrick Soon-Shiong

Neil P Desai

Paul Weingarten

Xiaowen Sun

Sherry Ci

Sharif Asad

Vuong Trieu

Forrest Arp

Anna B Juncker-Jensen

Lukasz Koroniak

David Ho

The present invention relates to the use of substituted pyrazole derivatives to modulate tropomyosin-related kinase (Trk) family protein kinase, and the use of the substituted pyrazole derivatives for the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.

Trk inhibition

The present invention provides antitumor agents comprising substituted pyrimidine derivatives and pharmaceutically-acceptable formulations thereof, methods for making novel compounds and methods for using the compounds. The compounds and compositions in accordance with the invention have utility in treatment of a variety of diseases and have kinase inhibitory activities.

Pyrimidine derivatives as kinase inhibitors and their therapeutical applications

The present invention relates to the use of substituted pyrimidine derivatives to modulate tropomyosin-related kinase (Trk) family protein kinase, and the use of the substituted pyrimidine derivatives for the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA. The present invention also provides compounds of the formula: as defined herein.

Pharmaceutical compounds, compositions, and methods are presented in which various heterocyclic thiosemicarbazone derivatives are prepared. Contemplated compounds will be suitable to inhibit or reduce cellular growth or proliferation and are thus beneficial in the manufacture of drugs to treat neoplastic diseases.

Heterocyclic thiosemicarbazone derivatives and their therapeutical applications

Compounds and compositions are presented that inhibit K-Ras, and especially mutant K-Ras. Certain compounds preferentially or even selectively inhibit specific forms of mutant K-Ras, and particularly the G12D mutant form.

Compositions and methods of targeting mutant K-ras

The present invention relates generally to the use of compounds to treat a variety of disorders, diseases and pathologic conditions and more specifically to the use of substituted indol-5-ol derivatives to modulate protein kinases and for treating protein kinase-mediated diseases.

Substituted indol-5-ol derivatives and their therapeutic applications

Substituted indol-5-ol derivatives and their therapeutical applications

The invention provides triazine compounds and methods of their use to modulate protein kinases and to treat diseases mediated by said protein kinases.

Benzyl substituted triazine derivatives and their therapeutical applications

The invention provides Triazine derivatives and further provides methods of using these compounds to modulate protein kinases and for treating diseases and conditions mediated by protein kinases.

Triazine derivatives and their therapeutical applications

The invention provides for Triazine derivatives and their use to modulate protein kinase activity in a variety of conditions and diseases.

Derivatives of dicarbonyl compounds having antitumor and antibiotic activity which can be used as anticancer agents.

Growing community of inventors

Alhambra, CA, United States of America

Qinwei Wang