Peking University

Qingzhou Zhang

Jun Huang

Zhen Yang

Fengxia Li

Chongguo Jiang

Jianxian Gong

Weibin Zhang

The present disclosure relates to a method of synthesizing cyclosporine derivatives. The method includes: providing a precursor fluid of the cyclosporine derivative, an alkaline fluid and a ClCHOCOCl solution; premixing the precursor fluid and the alkaline fluid to obtain a premixed solution; feeding the premixed solution into a first reaction chamber, reacting to prepare a first reaction liquid; feeding the first reaction liquid into a second reaction chamber, reacting the first reaction liquid with a COfluid to prepare a second reaction liquid; and reacting the second reaction liquid with the ClCHOCOCl solution.

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Shenzhen, China

Qingzhou Zhang