Teijin Limited

Qingzhi Gao

Kenji Manabe

Seiichi Ishizuka

Kazuya Takenouchi

Yasuhiro Takano

Ryo Sogawa

Atsuo Hazato

Hiroko Tanaka

Masayasu Tabe

Minoru Furuya

Yasuji Sakuma

Hiroaki Mitsuhashi

Tadashi Kishimoto

Manabu Chokki

Compounds expressed by the following general formula (1),[wherein, Rand Rare each independently a hydrogen atom or a protecting group for a hydroxyl group; Z is one out of the following formulae (1-1), (1-2), (1-3), (1-4) and (1-5)].The compounds can be used as active ingredients of treating agents for inflammatory respiratory diseases, malignant tumors, rheumatoid arthritis, osteoporosis, diabetes mellitus, hypertension, alopecia, acne, psoriasis, dermatitis, hypercalcemia, hypoparathyroidism and metabolic disorder of cartilage.

Vitamin D3 derivative and treating agent for inflammatory respiratory disease using same

Compounds expressed by the following general formula (1),[wherein, Rand Rare each independently a hydrogen atom or a protecting group for a hydroxyl group; Z is one out of the following formulae (1-1) to (1-5)].The compounds can be used as active ingredients of treating agents for inflammatory respiratory diseases, malignant tumors, rheumatoid arthritis, osteoporosis, diabetes mellitus, hypertension, alopecia, acne, psoriasis, dermatitis, hypercalcemia, hypoparathyroidism and metabolic disorder of cartilage.

Vitamin D, derivatives and remedies for inflammatory respiratory diseases containing the same

Vitamin D.sub.3 derivative and treating agent for inflammatory

A vitamin D.sub.3 derivative represented by the following formula: wherein, R is, independently, a hydrogen atom, tri(C.sub.1 to C.sub.7 hydrocarbon)silyl group, C.sub.2 to C.sub.8 acyl group, or group forming an acetal bond together with an oxygen atom of a hydroxyl group, A is ##STR1## where, R.sup.1 is a methyl group or methylene group, and when R.sup.1 is a methylene group, the bond between the R.sup.1 and the 3-position of the lactone ring is a double bond, R.sup.2 is a hydrogen atom or C.sub.1 to C.sub.3 alkyl group, R.sup.3 is a hydrogen atom, or R.sup.2 and R.sup.3 together indicate a substitutable single methylene group.

Vitamin D.sup.3 derivative and production process thereof

Vitamin D.sub.3 derivatives and production process thereof

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Tokyo, Japan

Qingzhi Gao