Merck + Co., Inc.

University of Texas System

Lexicon Pharmaceuticals, Inc.

Other

Qingyun Liu

Andrew D Howard

Kendra Carmon

Xing Gong

Leonardus H T Van Der Ploeg

Kevin R Lynch

Haiming Zhang

Wenxue Wu

Zhi-Cai Shi

Ying Wang

John W Hess

C Thomas Caskey

Ashok R Tunoori

David L Williams

Haihong Jin

Chengmin Zhang

Arokiasamy Devasagayaraj

Brett A Marinelli

Michael S Phillips

Fang Chen

Lakshama Samala

Karen Kulju McKee

Philip Manton Brown

Theodore N Mellin

Alison Strack

Ruiping Wang

Qingping Jiang

Terrence P McDonald

Brent Marinelli

Isolated or recombinant anti-LGR4 monoclonal antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer.

LGR4 specific monoclonal antibodies and methods of their use

A composition and method for detecting the ability of a compound to modulate the activity of LGR4, LGR5, or LGR6 receptors in a cell. LGR4, LGR5, and LGR6 are capable of activating the Wnt/&#x3b2;-catenin signaling system which plays essential roles in embryonic development and in the self-renewal and maintenance of adult stem cells.

Regulation of Wnt/beta-catenin signaling

Compounds of formulae I and II are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and manage serotonin-mediated diseases and disorders: 

Tryptophan hydroxylase inhibitors

Methods and compositions comprising tryptophan hydroxylase inhibitors are disclosed. Particular methods are directed at reducing or avoiding serotonin-mediated adverse effects associated with some drugs.

Methods of using and compositions comprising tryptophan hydroxylase inhibitors

A new neuromedin U receptor, designated NMUR2 has been found, which is involved in modulation of feeding behavior in mammals. Ligands of this receptor are able to modulate eating, and weight gain. Amino acid sequences of the human and rat forms, as well as their nucleic acid sequences are given.

Neuromedin U receptor NMUR2 and nucleotides encoding it

An isolated nucleic acid molecule is disclosed which encodes a novel human uncoupling protein (UCP3), and related recombinant expression vectors, recombinant host cells and substantially purified forms of the UCP3 protein. The isolated nucleic acid and proteins disclosed herein will be useful in methods associated with identifying compounds which modulate energy expenditure and body weight regulation, as well as effecting diseases such as obesity and diabetes as well as mitochondria-associated hypermetabolism. Additionally, the isolated nucleic acids of the present ivention are candidates for gene therapy of a mammalian host, including humans.

Human uncoupling protein 3

This invention relates to a new family of receptors, growth hormone secretagogue-related receptors, which exhibit moderate sequence identity to both the growth hormone secretagogue receptor (GHS-R) and the neurotensin receptor (NT-R). These newly identified receptors are expressed in a diverse set of tissues. This invention also relates to nucleic acids encoding these receptors, and to the use of these receptors to identify ligands that modulate growth hormone release as well as other modulators of endocrine function.

Growth hormone secretagogue related receptors and nucleic acids

The present invention features HG67 nucleic acids and HG67 polypeptides. HG67, also referred to herein as &ldquo;MCH-R2&rdquo;, is a G-protein coupled receptor having a high degree of sequence identity with MCH-R1. The amino acid sequence for HG67 is provided by SEQ. ID. NO. 1. The cDNA sequence of HG67 is provided by SEQ. ID. NO. 2.

Nucleic acid molecule encoding a melanin-concentrating hormone receptor 2 polypeptide

The rat ob receptor gene has been isolated and cloned. Two different alleles have been identified: the wild-type, and the fa-allele which differs from the wild type by only one base pair. The base pair change, however introduces an MspI restriction site into the DNA sequence, and also results in an amino acid change. Also part of the invention are the receptors, vectors containing the nucleic acid encoding the receptors, host cells transformed with this gene, and assays which use the gene or protein and identify new ligands.

Rat ob-receptors and nucleotides encoding them

Growing community of inventors

The Woodlands, TX, United States of America

Qingyun Liu