Zhejiang Huahai Pharmaceutical Co., Ltd.

Shanghai Synergy Pharmaceutical Sciences Co., Ltd.

Chinese Academy of Sciences

Shanghai Haihe Pharmaceutical Co., Ltd.

Qingyun Jiang

Xin Xu

Zhen Zhang

Yunfei Li

Yijin Wang

Jian Ge

Liming Zhang

Fengying Guo

Lei Liu

Jian Ding

Yi Chen

Meiyu Geng

Lei Jiang

Qiang Liu

Jia Chen

Hao Yu

Jing Su

Dongsheng Li

Jianhua Cao

Xiaobo Zhou

Xiaoer Xia

Xiaojuan Zhang

Kang Sun

Zhao Zhao

Xuxing Chen

Qianqian Shen

Yucai Yao

Linli Zhang

Qimei Wu

Jinqian Song

Chengxu Zang

Yuanfang Xiong

Yuyun Zhang

Provided are amide compounds, a preparation method therefor, and use thereof in the medical field. Specifically, provided are small molecule amide compounds. Such compounds are inhibitors of enhancer of Zeste homolog 2 (EZH2), and can be used for preventing and/or treating related diseases mediated by EZH2, including tumors, myeloproliferative diseases or autoimmune diseases.

Amide compounds, preparation method therefor, and use thereof in the medical field

Disclosed are a class of &#x3bc;-opioid receptor agonists and a preparation method therefor and the use thereof in the field of medicine, belonging to the field of medicinal chemistry. The &#x3bc;-opioid receptor agonists significantly increase the selectivity for a G protein signaling pathway, and not only can exhibit excellent pharmacodynamic effects, but also significantly improve safety.

&#x3bc;-opioid receptor agonist and preparation method therefor and use thereof in field of medicine

The present invention provides a pyrido five-element aromatic ring compound, and a preparation method therefor and a use thereof. The compound provided in the present invention has an inhibitory effect on wild-type and/or mutant EZH2, and is well positioned to become a novel anti-tumor drug or a drug for the treatment of autoimmune diseases.

Pyrido five-element aromatic ring compound, preparation method therefor and use thereof

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Shanghai, China

Qingyun Jiang