Xiamen University

Qingyan Xu

Xianming Deng

Ting Zhang

Zhiyu Hu

Wei Peng Huang

Zhou Deng

Xihuan Sun

Li Li

Xiaoyang Li

Jingfang Zhang

Yan Liu

Shuang Liu

Chao Dong

Xiaoxing Huang

Zhixiang He

Baoding Zhang

Zaiyou Yang

Jiaji Zhong

Yun Chen

Zhongji Zhuang

Wei Huang

Xinrui Wu

Qiaofeng Kang

Yanru Yang

A type of substituted penta-fused hexa-heterocyclic compounds having selective inhibition for PIKfyve kinase, a pharmaceutically acceptable salt and pharmaceutically acceptable solvate thereof, a method for the preparation thereof, a pharmaceutical composition comprising the same, and use of these compounds in the manufacture of a medicament for preventing or treating a disease associated with PIKfyve in vivo, in particular in the manufacture of a medicament for preventing or treating tumor growth and metastasis.

Substituted penta-fused hexa-heterocyclic compounds, preparation method therefor, drug combination and use thereof

The present invention relates to a compound having the following formula, or a stereoisomer thereof, a prodrug thereof, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof, preparation method thereof, pharmaceutical composition comprising the same and use of the compound in the manufacture of a medicament for preventing or treating tumor, wherein the substituents are as defined in the specification. 

Substituted aryl ether compound, preparation method thereof, pharmaceutical composition and use thereof

The present invention relates to a compound of formula I, a stereoisomer, a prodrug, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof, and a process for preparing the same, a pharmaceutical composition comprising the same, and use of the compound in the preparation of medicine preventing and treating tumors, wherein the substituents are as defined in the specification. 

Pyrimidopyrrole compounds, method for preparing the same, pharmaceutical compositions comprising the same and uses thereof

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Xiamen, China

Qingyan Xu