Abbvie Inc.

Calico Life Sciences LLC

Qingwei I Zhang

John T Randolph

Michael R Schrimpf

Zhiren Xia

Charles W Hutchins

Michael J Dart

Lawrence A Black

Jennifer M Frost

Lei Shi

Yunsong Tong

Marina Pliushchev

Ramzi Farah Sweis

Xiangdong Xu

Seungwon Chung

Andrew O Stewart

Kevin R Woller

Tao Li

Pramila A Bhatia

Richard J Perner

Sachin V Patel

Carmela Sidrauski

Kathleen J Murauski

Zhaoming Xiong

Kathleen Ann Martin

Marina A Pliushchev

Ramzi Farath Sweis

Marina Pliuschev

Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

Modulators of the integrated stress pathway

This invention relates to: (a) compounds and salts thereof that, inter alia, treat pain; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

Agents for treating pain and uses thereof

The present application relates to calcium channel inhibitors comprising compounds of formula (I), formula (II), formula (III), or formula (IV), wherein L, R, R, R, R, R, R, Rand Rare as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

(4-chloro-2-fluoro-N-(2-fluorophenyl)-5-[(8aR)-hexahydropyrrolo-[1,2-a]pyrazin-2(1H)-ylcarbonyl]-benzenesulfonamide, and pharmaceutically acceptable salts thereof

The present application relates to: (a) compounds of Formula (I): and salts thereof, wherein Z, Z, Z, Z, R, R, and Rare as defined in the specification; (b) compositions comprising such compounds and salts; and (c) methods of use of such compounds, salts, and compositions, particularly use as calcium channel inhibitors.

Substituted octahydropyrrolo[1,2-a]pyrazines as calcium channel blockers

The present application relates to: (a) compounds of Formula (I): and salts thereof, wherein Z', Z&#x2033;, L, G, R, and Rare as defined in the specification; (b) compositions comprising such compounds and salts; and (c) methods of use of such compounds, salts, and compositions, particularly use as calcium channel blockers.

[object Object]

Substituted piperidinylcarbonylbenzenesulfonamides as calcium channel blockers

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Libertyville, IL, United States of America

Qingwei I Zhang