Jiangsu Tasly Diyi Pharmaceutical Co., Ltd.

Qingwei Hou

Guocheng Wang

Wenzheng Liu

Hongguang Meng

Yu Xuan Zhang

Yu Zhang

Yuzhe Gao

Mingbo Yang

Hailong Yang

Qiaoping Cui

Zhanyuan Zhu

Jinping Liu

Provided are revaprazan hydrochloride polymorphs and a preparation method thereof. The method comprises a step of dissolving revaprazan hydrochloride in ethanol or aqueous solutions of ethanol having different proportions to perform recrystallization.

Revaprazan hydrochloride polymorphs and preparation method therefor

Provided is a preparation method for revaprazan hydrochloride, the method comprising: (1) the preparation of 4-hydroxyl-2-(4-fluoroaniline)-5,6-dimethylpyrimidine; (2) the preparation of 4-chloro-2-(4-fluoroaniline)-5,6-dimethylpyrimidine; (3) the preparation of revaprazan hydrochloride. The method has advantages such as simple operations, high product purity, good yield and suitability for industrial production.

Preparation method for revaprazan hydrochloride

Provided in the present invention are a new method for preparing the crystalline forms of Temozolomide and three types of crystalline form of Temozolomide by the method. Said method comprises the following steps: a Temozolomide is dissolved into dimethyl sulphoxide, a second organic solvent is added for recrystallization to prepare the crystalline forms of Temozolomide, wherein the second organic solvent is an alcohol, a ketone, a halohydrocarbon or an ester.

Crystalline forms of temozolomide and the method for preparing same

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Jiangsu, China

Qingwei Hou