Staidson (beijing) Biopharmaceuticals Co., Ltd.

Staidson Biopharmaceuticals Co., Ltd.

Qingshuang Zhang

Ming Liu

Lei Ma

Qun Huang

Ran Wu

Pingxia Zhu

The present application provides antibodies including antigen-binding fragment thereof that specifically recognizing Granulocyte-Macrophage Colony Stimulating Factor Receptor (GM-CSFRα). Also provided are methods of making and using these antibodies.

Antibodies specifically recognizing granulocyte-macrophage colony stimulating factor receptor alpha and uses thereof

The present disclosure relates to the field of biopharmaceuticals and provides a nerve growth factor (NGF) fusion protein and a preparation method and use thereof. The fusion protein has a general formula represented by A-B or A-L-B, wherein A is a nerve growth factor, L is a linker peptide, and B is an Fc moiety of IgG, or an analogue of the Fc moiety of IgG, or a fragment of the Fc moiety of IgG. The fusion protein of the present disclosure has the following advantages over a wild-type NGF: higher biological activity, a half-life extended more than 17 times, greatly reduced administration frequency, and significantly increased efficacy.

Nerve growth factor fusion protein, preparation method and use thereof

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Beijing, China

Qingshuang Zhang