Fudan University

Shanghai Miracogen Inc

Chinese Academy of Sciences

Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd.

Qingrou Li

Xuesai Zhang

Ke Yu

Qing Lin

Jingkang Shen

Tao Meng

Lanping Ma

Fei Xu

Le Zhao

Haomin Huang

Zhenping Zhu

Jianhe Chen

Provided is an antibody binding to human HER2 or an antigen-binding fragment thereof capable of specifically binding to human HER2. Compared with Perjeta, the combination of the antibody or an antigen-binding fragment thereof and Herceptin has improved biological activity in inhibiting the proliferation of tumor cells overexpressing HER2. The antibody or an antigen-binding fragment thereof has an antigen-binding epitope different from known antibodies binding to human HER2, can be used to prepare a drug for treating a disease related to HER2 overexpression, such as cancer, and has good prospects for clinical application.

Antibody binding to human HER2 and preparation method and use thereof

A tissue factor (TF)-targeted antibody-drug conjugate (ADC) and a method for preparing the ADC. The ADC is capable of binding to TF antigen with high specificity, and has high affinity, low immunogenicity, high cytotoxicity, and significant anti-tumor activity.

Tissue factor-targeted antibody-drug conjugate

The present invention provides a tissue factor (TF) monoclonal antibody and a preparation method therefor. The monoclonal antibody provided by the present invention can specifically bind with a TF antigen, has high affinity and low immunogenicity, and has the activity of resisting tumors and the like.

Antibody targeted to tissue factor, preparation method therefor, and use thereof

Growing community of inventors

Shanghai, China

Qingrou Li