Eye Institute of Shandong First Medical University

Institute of Ophthalmology Affiliated To Shandong First Medical University (shandong Institute of Ophthalmology, Qingdao Eye Hospital Affiliated To Shandong First Medical University)

Institute of Ophthalmology Affiliated To Shandong First Medical University (shandong Institute of Ophthalmo

Shandong First Medical University Affiliated Eye Institute (shandong Eye Institute/qingdao Eye Hospital of Shandong First Medical University)

Qingjun Zhou

Weiyun Shi

Hongwei Wang

Bin Zhang

Hui Jiang

Bining Zhang

Ping Lin

Huifang Ren

Hengrui Zhang

Shengqian Dou

Shuqin Meng

Lixin Xie

Fangying Song

Dongfang Li

Qun Wang

Chaoying Wang

Zongyi Li

Xinhang Wang

Chunxiao Dong

Haoyun Duan

The present disclosure provides a method for building a finite element model of corneal endothelial cells, including: importing a standard corneal model into finite element pre-processing software, and generating 2D meshes, to obtain a basic mesh model; importing a detailed geometric model of corneal endothelial cells; determining a complete corneal endothelial cell model according to the basic mesh model and the detailed geometric model; and performing calculation according to the complete corneal endothelial cell model. The present disclosure can improve the efficiency and effect of building a finite element model of corneal endothelial cells.

Method for building finite element model of corneal endothelial cells

A preparation method of a double-network versatile hydrogel with antibacterial and drug sequential release capabilities is provided in the present disclosure, belonging to the technical field of biological corneas. The preparation method includes the following steps: mixing filipin protein-methacrylate, glycidyl methacrylate functionalized quaternized chitosan, polydeoxyribonucleotide, and lithium phenyl(2,4,6-trimethylbenzoyl) phosphinate with drug-loaded micelles, followed by cross-linking under irradiation of ultraviolet to construct a double-network versatile hydrogel with antibacterial and drug sequential release capabilities.

Double-network versatile hydrogel with antibacterial and drug sequential release capabilities

In view of the problem that the current prevention and treatment manners for corneal neovascularization (CNV) may cause complications, the present disclosure provides an application of CB-839 in preparation of a drug for inhibiting CNV. The CB-839-loaded drug of the present disclosure can significantly inhibit CNV in mice and reduce the infiltration of inflammatory cells without obvious side effects, which makes up for the shortcoming of the prior art.

Application of CB-839 in preparation of drug for inhibiting corneal neovascularization (CNV)

A preparation method of a nanozyme composite-based hybrid hydrogel eye drop includes synthesizing a tannin-coordinated silver/cobalt composite nanoparticle through a coordination reaction of cobalt chloride hexahydrate with ammonia water and an oxidation-reduction reaction of silver nitrate with tannin; and mixing the silver/cobalt composite nanoparticle with an acrylate-modified gelatin, conducting an ultrasonic treatment to allow complete dissolution, and irradiating a resulting mixture under ultraviolet (UV) light to obtain the nanozyme composite-based hybrid hydrogel eye drop. The preparation method of the present disclosure has simple operations and a short preparation time. The eye drop prepared by the preparation method shows a broad-spectrum bactericidal effect against a variety of bacteria and fungi, and has prominent preventive and therapeutic effects for bacterial and drug-resistant bacterial corneal infections.

Preparation method of nanozyme composite-based hybrid hydrogel eye drop

Long-chain non-coding RNA NEAT1 are used in the preparation of drugs for the treatment of Fuchs' endothelial corneal dystrophy. Overexpression of the long-chain non-coding RNA NEAT1 can effectively reduce corneal endothelial damage, alleviate the symptoms of corneal edema, can be used for the treatment of Fuchs' endothelial corneal malnutrition.

Adeno-associated virus for activating RNA-NEAT1 over-expression and applications thereof

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Qingdao, China

Qingjun Zhou