Amgen Inc.

Qingge Xu

Julio Cesar Medina

Zice Fu

Jiwen Liu

Yingcai Wang

Michael J Schmitt

Xi Alan Huang

H Lucy Tang

Jonathan B Houze

Liusheng Zhu

Feng Xu

Alan X Huang

Xuemei Wang

Tassie Collins

Hossen Mahmud

Lucy H Tang

Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related diseases and conditions. In particular, the invention provides compounds which modulate the function and/or expression of proteins involved in atopic diseases, inflammatory conditions and cancer. The subject compounds are carboxylic acid derivatives.

Asthma and allergic inflammation modulators

Compounds, compositions and methods are provided that are useful in the treatment of chemokine receptor-mediated conditions and diseases. In particular, the invention provides compounds which modulate CCR4 function or a CCR4-mediated response. The subject compounds and compositions are useful for the treatment or prevention of inflammatory conditions and diseases.

CCR4 antagonists

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Burlingame, CA, United States of America

Qingge Xu