Cell Signaling Technology, Inc.

Qingfu Zeng

Ailan Guo

Klarisa Rikova

Roberto Polakiewicz

Kimberly A Lee

Katherine Eleanor Crosby

The invention discloses a previously unidentified subset of mammalian non-small cell lung carcinomas (NSCLC) in which platelet-derived growth factor receptor alpha (PDGFR&#x3b1;) is expressed and is driving the disease, and provides methods for identifying a mammalian NSCLC tumor that belongs to a subset of NSCLC tumors in which PDGFR&#x3b1; is expressed, and for identifying a NSCLC tumor that is likely to respond to a PDGFR&#x3b1;-inhibiting therapeutic. The invention also provides methods for inhibiting the progression of a mammalian NSCLC tumor in which PDGFR&#x3b1; is expressed, and for determining whether a compound inhibits the progression of a PDGFR&#x3b1;-expressing mammalian NSCLC tumor.

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Hamilton, MA, United States of America

Qingfu Zeng