Jenkem Technologyco., Ltd.. (tianjin)

Jenkem Technology Co., Ltd.

Cansino (shanghai) Biological Research Co., Ltd.

Qingbin Wang

Xuan Zhao

Jinliang Wang

Zewang Feng

Meina Lin

Jian Liu

Xuefeng Yu

Yanli Xiong

Yu Li

Yanping Song

Leimin Wang

Jinghui Du

Jie Qi

Tao Zhu

Jun Guo

Zhihong Yan

Baitao Zhang

Shuzhen Hu

Jing Hao

Changyou Zhu

Jingyun Hu

Juan Shi

The disclosure discloses a linker compound, a polyethylene glycol-linker conjugate and a derivative thereof, and a polyethylene glycol-linker-drug conjugate. The linker compound as well as the conjugate thereof with the polyethylene glycol and the derivative thereof may be used for modifying a drug, and a modification reaction is simple and easy to carry out. Moreover, a reaction yield is high, and an application range of the modified drug is wide. The modified drugs gradually degrade from a chain of the conjugate in vivo, and may stay in a lesion (such as a cancer site) for a longer period of time, achieving purposes of sustained and controlled release, reducing an administration frequency, and greatly improving a bioavailability of the drug and a patient compliance.

Linker compound, polyethylene glycol-linker conjugate and derivative thereof and polyethylene glycol-linker-drug conjugate

Growing community of inventors

Tianjin, China

Qingbin Wang