Novartis Ag

The General Hospital Corporation

Massachusetts General Hospital Corporation

Qing Sheng

Seth Alexander Ettenberg

Nicole Haubst

Xizhong Huang

Christian Carsten Silvester Kunz

Winfried Elis

Andrew Paul Garner

Elizabeth Anne Reisinger Sprague

Rakesh K Jain

Dai Fukumura

Vasileios Askoxylakis

Gino B Ferraro

David P Kodack

Seth Ettenberg

Christian Carsten Kunz

The present invention relates to a pharmaceutical combination which comprises (a) a phosphatidylinositol 3-kinase inhibitor or pharmaceutically acceptable salt thereof, and (b) a Her3 antagonist, for simultaneous, separate or sequential administration for the treatment of breast cancer brain metastases; a method of treating a subject having a breast cancer brain metastases comprising administration of said combination to a subject in need thereof; use of such combination for the treatment of breast cancer brain metastases; and a commercial package comprising such combination.

Treatment of breast cancer brain metastases

This invention relates to antibodies or fragments thereof which interact with HER family of receptors, e.g., HER3 receptor. In particular, it relates to antibodies or fragments thereof that recognize a conformational epitope of HER3 receptor comprising residues from both domains 2 and 4 resulting in inhibition of both ligand-dependent and ligand-independent signal transduction; and allow ligand binding (e.g., neuregulin), while preventing ligand-induced activation of signal transduction. These antibodies or fragments can be used to treat a number of diseases or disorders characterized by increased levels of HER3 expression (e.g., esophageal cancer). These antibodies or fragments can be used to treat a number of diseases or disorders characterized by the antibodys or fragments ability to decrease tissue weight (e.g., prostate or uterine weights) or to induce atrophy of tissue (e.g., atrophy of male breast).

Antibodies for epidermal growth factor receptor 3 (HER3)

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Sharon, MA, United States of America

Qing Sheng