Daewoong Pharmaceutical Co., Ltd.

Liaoning Daewoong Fharmaceutcal Co., Ltd.

Liaoning Daewoong Pharmaceutical Co., Ltd.

Qing Ri Li

Hee Kyoon Yoon

Sang Ho Seol

Chao Tong

Ye Chang

Tie Li

A method of preparing an intermediate useful for the synthesis of a diphenylmethane derivative that can be used as an SGLT inhibitor is described. A method of synthesizing a compound of Formula 7 can address problems of existing synthesis processes requiring the synthesis of the Grignard reagent and management of related substances. In addition, the method can minimize the generation of related substances, and thus does not require reprocessing of reaction products, thereby simplifying the process. Accordingly, the production yield of a diphenylmethane derivative can be maximized.

Method for producing intermediate useful for synthesis of SGLT inhibitor

The present invention provides a suspension comprising aluminum hydroxide and magnesium hydroxide and a method of preparing the same. The aqueous suspension composition according to the present invention ensures an excellent sedimentation rate by using a mixed suspending agent with a specific composition, so that insoluble aluminum hydroxide and magnesium hydroxide do not easily settle, do not form a cake, and are easily redispersed. Since the aqueous suspension composition having an excellent sedimentation rate has not only physical stability, but also forms a homogeneous dispersion system, the reproducibility or effectiveness of bioavailability may be ensured. In addition, the aqueous suspension composition according to the present invention provides an excellent texture, and thus patient compliance increases.

Suspension comprising aluminum hydroxide and magnesium hydroxide and preparation method therefor

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Benxi, China

Qing Ri Li